Inclusion criteria for patients who will be operated
- Diagnosis of idiopathic Parkinson's disease (according to the criteria of the United Kingdom Parkinson's Disease Society Brain Bank)
- Age between 18 and 70;
- Motor complications in the form of fluctuations in motor state or dyskinesias induced by dopaminergic therapy, despite medical treatment optimum;
- Other medical conditions that are stable or do not interfere with the procedure proposed;
- Excellent responsiveness to levodopa (UPDRS motor score improvement greater than 50% in the acute levodopa test)
- Brain MRI without abnormality
- Normality of biological examinations
- Person who has voluntarily and informedly agreed to participate in the study (signature of a written consent)
- Patient with social health insurance
Criteria for non-inclusion of Parkinsonian patients who will be operated
- Contraindication to examinations necessary for inclusion
- Evolutionary psychiatric pathology;
- Dementia(MMS<24/30);
- Patients with a medical condition that makes surgery dangerous neuro-surgical;
- Bleeding-promoting diseases and laboratory test abnormalities clotting;
- Existence of contraindications to MRI (cardiac or neural pacemaker, clips ferromagnetic surgeries, implants and metal objects, foreign bodies intraocular, pregnancy, claustrophobia).
- Taking drugs interfering with coagulation for 1 month before intervention.
- Persons under guardianship, curatorship or any other administrative or judicial measure deprivation of rights and liberty
Selection criteria for non-operated patients
- Diagnosis of idiopathic Parkinson's disease (according to the criteria of the United Kingdom Parkinson's Disease Society Brain Bank);
- Age between 18 and 70;
- Other medical conditions that are stable or do not interfere with the proposed protocol;
- Presence of axial signs (gait and/or balance disorders) no improved by antiparkinsonian treatment
- Brain MRI without notable abnormality
- Normality of biological examinations
- Person who has voluntarily and informedly agreed to participate in the study (signature of a written consent)
- Patient with social health insurance
Criteria for non-inclusion of non-operated patients
- Contraindication to examinations necessary for inclusion
- Progressive psychiatric pathology;
- Dementia (MMS<24/30);
- Existence of contraindications to MRI (cardiac or neural pacemaker, clips ferromagnetic surgeries, implants and metal objects, foreign bodies intraocular, pregnancy, claustrophobia).
- Persons under guardianship, curatorship or any other administrative or judicial measuredeprivation of rights and liberty
Inclusion criteria for group 3 patients (already operated)
- Diagnosis of idiopathic Parkinson's disease (according to the criteria of the United Kingdom Parkinson's Disease Society Brain Bank);
- Bilateral deep brain stimulation of the subthalamic nucleus for more than 1 year
- Age between 18 and 70;
- Person who has voluntarily and informedly agreed to participate in the study (signature of a written consent)
- Patient with social health insurance
Criteria for non-inclusion of Parkinsonian patients (already operated)
- Contraindication to examinations necessary for inclusion
- Evolutionary psychiatric pathology;
- Dementia(MMS<24/30);
- Persons under guardianship, curatorship or any other administrative or judicial measure deprivation of rights and liberty
Inclusion criteria for healthy subjects
- Age between 18 and 70 years old
- Normal neurological examination
- Person who voluntarily and informedly agreed to participate in the study (signature of a written consent)
- Patient with social health insurance
Criteria for non-inclusion of healthy subjects
- Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of rights and freedom
- Existence of neurological, orthopedic or psychiatric history
- Existence of contraindications to MRI (cardiac or neural pacemaker, ferromagnetic surgical clips, implants and metallic objects, foreign bodies intraocular, pregnancy, claustrophobia).