Institution changed surgical method to small-incision lenticule extraction. Study never started.

Laser in situ keratomileusis is a successful procedure for the treatment of low to moderate myopia.

Advances over the last decade have allowed LASIK to also correct higher order wavefront aberrations. In low myopia, there seem to be a minor effect of such wavefront-guided treatment. However, it remains to be established whether there is a beneficial effect in higher degrees of myopia.

The study aims to determine whether myopic subjects (-6 to -10 diopters) with higher-than-average preoperative higher-order aberrations have benefit of wavefront-guided treatment. Subjects are randomized to wavefront-guided treatment in one eye, and conventional treatment in the other.

Inclusion Criteria:

• Age 20 to 50 years
• No known ocular or systemic disease
• Not pregnant or breastfeeding
• Myopia between -6.0 and -10.0 diopters
• Astigmatism below 2.0 diopters
• Difference of less than 1.0 diopters in spherical equivalent between eyes
• Normal corneal topography
• Corneal thickness sufficient for planned treatment

Exclusion Criteria:

• Patients that do not fulfill inclusion criteria
• Insufficient quality of ocular wavefront measurement