D-cycloserine Augmented CBT for Panic Disorder

The Effect of a Single-dose of D-cycloserine on the Basic Effects of Cognitive-behaviour Therapy for Panic Disorder - a Randomized Placebo-controlled Trial

The purpose of this study is to determine whether d-cycloserine augments the clinical effects of exposure-based cognitive-behaviour therapy for panic disorder.

Inclusion Criteria:

• clinical diagnosis of panic disorder
• at least moderate agoraphobic avoidance

Exclusion Criteria:

• psychoactive medication last 6 weeks
• exposure-based cognitive-behaviour treatment for panic disorder and agoraphobia during last 3 months
• female participant who is pregnant or breast-feeding
• lifetime history of psychosis, bipolar disorder, alcohol, medication or drug abuse or dependence; current primary depressive disorder
• lifetime history of epilepsy or other significant disease or disorder