Adenosine-induced Stress Dynamic Myocardial Perfusion Imaging With Dual-source CT

This study was designed as a prospective multicenter trial to determine the accuracy of combined CT coronary angiography and perfusion imaging, specifically quantitative dynamic perfusion imaging in patients with suspicious coronary artery disease compared conventional coronary angiography and quantitative dynamic perfusion MRI as standard reference.

Inclusion Criteria:

1. Men and women patients, with age ranging 40-80.
2. Suspected coronary artery disease who are supposed to undergo invasive coronary angiography with appropriate clinical indications
3. Patients who are willing to sign the informed consent form

Exclusion Criteria:

1. Contraindication of CT Known allergy to iodinated contrast media or history of contrast-induced nephropathy Decreased renal function: elevated serum creatinine(>1.5mg/dl) Contraindication to beta-blockers Severe arrhythmia: arterial fibrillation or uncontrolled tachyarrhythmia, or advanced atrioventricular block (second or third degree heart block)
2. Contraindication of MRI Claustrophobia Metallic hazards Pacemaker implant eGFR<30 ml/min
3. Unstable or uncooperative patients
4. Limited life expectancy due to cancer or end-stage renal or liver disease
5. Evidence of severe symptomatic heart failure (NYHA Class III or IV)
6. Previous myocardial infarction, coronary artery intervention, coronary artery bypass surgery, or other cardiac surgery