Prospective Study In Noninvasive Evaluation of Hepatic Fibrosis in Chronic Hepatitis B

Prospective Study In Noninvasive Evaluation of Hepatic Fibrosis in Chronic

The aim of our study is to evaluate liver fibrosis using biochemical markers, FibroScan, and radiology methods in patients with chronic hepatitis B in mainland China.

Up to Nov, 2015, total of 818 patients with chronic HBV infection had been enrolled in the study. Paired blood and liver biopsy specimen had been collected. The serum samples stored at -80 degree Celsius. All the liver biopsy samples were judged by three pathology experts, according to Ishak standard.

Inclusion Criteria:

• clinical diagnosis of chronic hepatitis B or compensated cirrhosis due to chronic hepatitis B virus infection
• agree to have liver biopsy

Exclusion Criteria:

• clinical diagnosis of decompensated cirrhosis due to hepatitis B virus or inactive carrier
• liver diseases due to other origin