Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Oslo Metropolitan University | OTHER |
| Mills DA | INDUSTRY |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to investigate blood LDL-cholesterol and level of inflammatory markers after intake of food items with different fatty acid composition.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Food items | Experimental | Food items low in saturated fat and high in polyunsaturated fat |
|
| Control food items | Placebo Comparator | Food items containing saturated fat and polyunsaturated fat according to a traditional Norwegian diet |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Food items | Other | Food items with different fatty acid composition |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in LDL-cholesterol | Change in LDL-cholesterol when compared to control diet | Change from baseline after 8 weeks |
| Change in total cholesterol | Change in total cholesterol when compared to control diet | Change from baseline after 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Inflammatory markers in circulation and at gene expression level in PBMC | Inflammatory markers are measured at baseline and after 8 weeks intervention in circulation and at gene expression level in PBMC | |
| Markers of lipid metabolism at gene expression level in PBMC |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Stine Ulven, PhD | University of Oslo | Principal Investigator |
| Kirsten B Holven, PhD | Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Oslo | Oslo | 0316 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34999928 | Derived | Pigsborg K, Gurdeniz G, Rangel-Huerta OD, Holven KB, Dragsted LO, Ulven SM. Effects of changing from a diet with saturated fat to a diet with n-6 polyunsaturated fat on the serum metabolome in relation to cardiovascular disease risk factors. Eur J Nutr. 2022 Jun;61(4):2079-2089. doi: 10.1007/s00394-021-02796-6. Epub 2022 Jan 9. | |
| 31051508 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Markers of lipid metabolism at gene expression level in PBMC is measured at baseline and after 8 weeks of intervention |
| Appetite hormones | Appetite hormones is measured at baseline and after 8 weeks of intervention |
| Gut peptides | Gut peptides are measured at baseline and after 8 weeks of intervention |
| Metabolites | Targeted and untargeted metabolomics will be measured | Metabolites are measured at baseline and after 8 weeks of intervention |
| Whole genome gene expression | Microarray | whole genome gene expression profiles are measured at baseline and after 8 weeks of intervention |
| Ulven SM, Christensen JJ, Nygard O, Svardal A, Leder L, Ottestad I, Lysne V, Laupsa-Borge J, Ueland PM, Midttun O, Meyer K, McCann A, Andersen LF, Holven KB. Using metabolic profiling and gene expression analyses to explore molecular effects of replacing saturated fat with polyunsaturated fat-a randomized controlled dietary intervention study. Am J Clin Nutr. 2019 May 1;109(5):1239-1250. doi: 10.1093/ajcn/nqy356. |