The Clinical Trail Of NAFLD Treated By Traditional Chinese Medicine

The Clinical Trail Of NAFLD Treated By Traditional Chinese Medicine

To investigate in subjects with non-alcoholic fatty liver disease the direct effects of a Chinese herb formula.

1) Liver fat (measured by CT scan) and liver function assessed by liver enzymes levels; 2) Insulin sensitivity measured by HOMA index, oral glucose tolerance test (OGTT) and a euglycaemic hyperinsulinaemic clamp (with stable isotopes) in a subset of the subjects; 3) Plasma lipid profile and non esterified fatty acids (NEFA) concentration; 4) Circulating levels of adipokines.

Inclusion Criteria:

• subjects with NAFLD(nonalcoholic fatty liver disease) (criteria of Society of Hepatology, Chinese Medical Association, 2002.10),
• aged 18-65
• alcohol consumption less than 40g/week;
• liver/spleen (L/S) ratio no more than 1 by CT scan.

Exclusion Criteria:

• ALT more than twice the upper end of the normal range
• viral hepatitis
• total parenteral alimentation or secondary liver disease such as hepatocirrhosis, autoimmune hepatitis, metabolic liver disease or drug induced liver disease
• severe cardiovascular or renal dysfunction
• Subjects with diabetes (fasting glucose more than or equal to 7.0mmol/L or postprandial glucose more than or equal to 11.1mmol/L)
• Subjects treated with statins