The purpose of this study is to collect safety data on ALFALASTIN® infusions performed at home or in out-of hospital locations.

Non interventional, observational, longitudinal, prospective, multicenter, non comparative study.

Participation Criteria:

• Patients above 18 y.o,
• suffering from severe forms of primary alpha-1 antitrypsin deficiency, phenotype PiZZ or PiSZ with pulmonary emphysema,
• currently treated as per routine practice, once a week, by ALFALASTIN® at home or in out-of-hospital location
• and having signed informed consent.

Patients above 18 y.o, suffering from severe forms of primary alpha-1 antitrypsin deficiency, phenotype PiZZ or PiSZ with pulmonary emphysema, currently treated , once a week, as per routine practice by ALFALASTIN® at home or in out-of-hospital location.