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The purpose of this study is to compare two surgical methods of adrenalectomy. One is called PRA(posterior retroperitoneal adrenalectomy), which is performed through 3 or 4 holes at patient's back. The other is LA(laparoscopic adrenalectomy) which is performed through patient's abdominal cavity after making 3 or 4 holes in the abdomen.
Since 1992, transabdominal LA(laparoscopic adrenalectomy) has been a standard method of adrenalectomy. This traditional method has been used widely because this procedure provides wide view of the whole abdomen which is familiar to surgeons. But due to its unique location at retroperitoneum, adrenal is still not easy to approach. So various retroperitoneal approaches were designed and adjusted. Among those, PRA(posterior retroperitoneal adrenalectomy) has showed good outcomes in many institutes. PRA facilitates direct approach to kidney and adrenal gland, and so operative time can be shortened. But there has been no randomized controlled trial between these two methods.
Therefore, as experienced surgeons in both methods, we want to practice this study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PRA | Experimental | Persons who get PRA surgery. |
|
| LA | Experimental | Persons who get LA surgery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PRA | Procedure |
| ||
| LA | Procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Operation time | operation time will be measured by attending nerse | Participants will be followed until the first visit of out patients clinic after discharge, an expected average of 3 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Pain sensation after surgery | Pain score will be described daily during hospitalization, and also at out patient clinic after discharge | Participants will be followed until the first visit of out patients clinic after discharge, an expected average of 3 weeks |
| Recovery of bowel movement |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kyueun Lee, Ph.D | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29189215 | Derived | Chai YJ, Yu HW, Song RY, Kim SJ, Choi JY, Lee KE. Lateral Transperitoneal Adrenalectomy Versus Posterior Retroperitoneoscopic Adrenalectomy for Benign Adrenal Gland Disease: Randomized Controlled Trial at a Single Tertiary Medical Center. Ann Surg. 2019 May;269(5):842-848. doi: 10.1097/SLA.0000000000002603. |
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| ID | Term |
|---|---|
| D000307 | Adrenal Gland Diseases |
| D010673 | Pheochromocytoma |
| D006929 | Hyperaldosteronism |
| D003480 | Cushing Syndrome |
| C538238 | Adrenal incidentaloma |
| ID | Term |
|---|---|
| D004700 | Endocrine System Diseases |
| D010235 | Paraganglioma |
| D018358 | Neuroendocrine Tumors |
| D017599 | Neuroectodermal Tumors |
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|
Gas out is regarded as a recovery of bowel movement |
| Participants will be followed the duration of hospital stay, an expected average of 5 days |
| Wound complication | Participants will be followed until the first visit of out patients clinic after discharge, an expected average of 3 weeks |
| Blood loss during operation | Participants will be followed until the first visit of out patients clinic after discharge, an expected average of 3 weeks |
| Intra-operative hemodynamic status | Events as below will be recorded and compared severe hypertension(systolic BP>200mmHg), severe hypotension(systolic BP<90mmHg), Tachycardia(HR>110/min), Bradycardia(HR<50/min) | Participants will be followed until the first visit of out patients clinic after discharge, an expected average of 3 weeks |
| D009373 |
| Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009380 | Neoplasms, Nerve Tissue |
| D000308 | Adrenocortical Hyperfunction |