The insertion of long-lasting intravenous device is done under local anesthesia. Currently, in the investigators hospital, no premedication is given to the patients. However, this procedure occurs in a particular emotional context related to the diagnosis of cancer or malign hemopathies.

Therefore, administration of a sedative or anxiolytic drugs before the start of the procedure can be questionable.

Hydroxyzine is the reference molecule for premedication because of its anxiolytic and anti-histaminic properties A new agent, pregabalin, shares also the same properties

The main objective of this study was to compare the efficacy of pregabalin and hydroxyzine on the anxiety score as a premedication during the insertion of long-lasting intravenous device under local anesthesia.

Inclusion Criteria:

• Patients aged from 18 to 75 years
• Patient schedules for insertion of long-lasting intravenous device

Exclusion Criteria:

• History of previous insertion of long-lasting intravenous device or central intravenous catheter
• long term treatment of gabapentin or pregabalin
• Hypersensitivity to pregabalin or any of the excipients
• Hypersensitivity to hydroxyzine, one of its metabolites, one of the excipients, another derivative of piperazine, aminophylline or ethylene diamine.
• Patient at risk of glaucoma e
• Patient at risk for urinary retention
• Patient severe respiratory failure
• Patient at the general condition not too corrupted (ASA IV)
• Renal failure with creatinin clearance < 30 ml / min
• Patient not affiliated to Social Security
• Pregnant or lactating
• Patients in emergency situations
• Inpatient without consent