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The main objective was to test the hypothesis that adding lidocaine to hyperbaric levobupivacaine could change the duration of levobupivacaine spinal block.
A satisfactory spinal anaesthesia requires both a fast onset and proper duration at the same time. Transurethral resection of the prostate (TUR-P) is a surgery of medium duration. The addition of lidocaine to hyperbaric bupivacaine shortens the duration of bupivacaine spinal block and therefore provides more rapid recovery. This property of lidocaine is not verified with other local anesthetics. Levobupivacaine is a S-enantiomer of racemic bupivacaine and is a long acting local anesthetic.The aim of this prospective randomized controlled study was to investigate this effect of lidocaine, with a local anesthetic other than bupivacaine. It was hypothesized that the duration of the intrathecal block could change when performed with hyperbaric levobupivacaine mixed with low dose lidocaine and this technique could be consistent for the duration of TUR-P surgery. Participants will be followed on the day of surgery for primary and secondary outcome measures and 3 days postoperatively for complications (TNS).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group Levobupivacaine lidocaine | Experimental | Group Levobupivacaine lidocaine Spinal anesthesia with 1.5 ml hyperbaric levobupivacaine (6.75 mg) + 0.3 ml 2 % lidocaine |
|
| Group Control | Active Comparator | Group Control levobupivacaine spinal anesthesia with levobupivacaine (6.75 mg) + saline |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Levobupivacaine lidocaine spinal anesthesia | Drug | Spinal anesthesia |
|
| Measure | Description | Time Frame |
|---|---|---|
| The duration of the spinal block (S1 regression of the block) | the time between the intrathecal injection and sensorial block regression to S1 dermatome, measured in minutes | participanta will be followed on the operation day |
| Measure | Description | Time Frame |
|---|---|---|
| postoperative care unit stay | the time between the patient entered the PACU and left the PACU (when the sensorial block was regressed to S1 dermatome and the patient fulfilled an Aldrete score higher or equal to 9), measured in minutes | participants will be followed on the operation day |
| Measure | Description | Time Frame |
|---|---|---|
| maximum block level | the dermatomal level that the sensorial block reached, determined with the pin prick test, expressed with dermatomes | participants will be followed on the operation day |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Taylan Akkaya, MD | Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital, Turkey. | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital | Ankara | 06110 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18713891 | Background | Lee SJ, Bai SJ, Lee JS, Kim WO, Shin YS, Lee KY. The duration of intrathecal bupivacaine mixed with lidocaine. Anesth Analg. 2008 Sep;107(3):824-7. doi: 10.1213/ane.0b013e3181806149. |
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| ID | Term |
|---|---|
| D011470 | Prostatic Hyperplasia |
| ID | Term |
|---|---|
| D011469 | Prostatic Diseases |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D000077554 | Levobupivacaine |
| D008012 | Lidocaine |
| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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| levobupivacaine Spinal anesthesia | Drug | spinal anesthesia |
|
|
| D052801 |
| Male Urogenital Diseases |
| Aniline Compounds |
| D000588 | Amines |
| D000083 | Acetanilides |