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The purpose of this study is to investigate the efficacy of two different corticosteroid ointment application regimens for the treatment of eczema (atopic dermatitis).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Soak and smear | Active Comparator | Application of hydrocortisone 2.5% ointment or triamcinolone acetonide 0.1% ointment immediately to wet skin once a day and dry skin once a day. |
|
| Dry smear | Active Comparator | Application of hydrocortisone 2.5% ointment or triamcinolone acetonide 0.1% ointment to dry skin twice a day. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Soak and smear | Other | Corticosteroid ointment applied to wet skin once a day and dry skin once a day. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy of corticosteroid application regimen as assessed by the Eczema Area and Severity Index (EASI) | 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of corticosteroid ointment application regimens on serum cortisol | 2 weeks after application of topical corticosteroids | |
| Frequency of atopic dermatitis flares in the 3 months following the two-week treatment regimen | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Richard J Antaya, MD | Yale University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yale University | New Haven | Connecticut | 06510 | United States |
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| ID | Term |
|---|---|
| D003876 | Dermatitis, Atopic |
| D004485 | Eczema |
| ID | Term |
|---|---|
| D012873 | Skin Diseases, Genetic |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003872 | Dermatitis |
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| Dry Smear | Other | Corticosteroid ointment applied to dry skin twice a day. |
|
| Adverse effects associated with each corticosteroid application regimen | Characterize and quantify adverse effects associated with each corticosteroid application regimen. | 3 months |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D017443 | Skin Diseases, Eczematous |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |