Early stage diagnosis of gastric cancer has ensued different approaches in its resection strategies. In order to increase the proportion of cases that undergo radical resection and reduce the recurrence rate, different pre-operative treatments are introduced. Here, the investigators investigate an active preoperative chemotherapeutic regimen to in patients with locally advanced gastric cancer.

Inclusion Criteria:

• Tissue diagnosis of gastric or gastroesophageaql junction Adenocarcinoma
• T3, T4 any N with non metastatic condition
• Age 18 - 70 years
• Performance status 0,1 according to ECOG criteria
• Adequate bone marrow , liver and renal function
• Hemoglobin ≥ 11 g/dl
• Platelets ≥ 100000 / mm3
• Absolute Neutrophil Count ≥ 1500/mm3
• Normal Bilirubin
• Normal Transaminases
• Normal creatinin
• Absence of active co-morbid illness (uncontrolled infection, uncontrolled DM, cardiopulmonary disease)

Exclusion Criteria:

• Any metastatic disease, T1, T2, N0