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Chronic thromboembolic pulmonary hypertension (CTEPH) has been associated with increased morbidity and mortality. Patients with pulmonary embolism (PE) have elevated risk for development of CTEPH. It is not known, whether the location of pulmonary embolism (central vs. peripheral) nor fibrinolysis have an impact of CTEPH incidence. This study has been performed to assess the CTEPH incidence in different populations: in patients with central vs. peripheral PE and in patients with or without fibrinolysis therapy for PE.
The embolus localization during index pulmonary embolism might be of potential relevance for CTEPH development.
In the present study patients with confirmed pulmonary embolism for at least 12 months will be screened for CTEPH. The incidence of CTEPH will be correlated to thrombus location (central vs. peripheral) and the index use of fibrinolysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PE peripheral with fibrinolysis | Patients with peripheral PE who received fibrinolysis therapy | ||
| PE peripheral, no fibrinolysis | Patients with peripheral PE who did not receive fibrinolysis | ||
| PE central with fibrinolysis | Patients with central PE who received fibrinolysis therapy | ||
| PE central, no fibrinolysis | Patients with central PE who did not receive fibrinolysis |
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| Measure | Description | Time Frame |
|---|---|---|
| CTEPH | Incidence of CTEPH | participants will be followed at least one year after acute pulmonary embolism, an expected average of 5 years follow-up is estimated |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who were hospitalized for acute pulmonary embolism at the University Hospital of Cologne.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fikret Er, MD | Contact | +49-221-478-32396 | fikret.er@uk-koeln.de | |
| Natig Gassanov, MD | Contact | +49-221-478-32354 | natig.gassanov@uk-koeln.de |
| Name | Affiliation | Role |
|---|---|---|
| Fikret Er, MD | University of Cologne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Heart Center of the University Hospital of Cologne | Recruiting | Cologne | North Rhine-Westphalia | 50937 | Germany |
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