The purpose of this study is to evaluate the safety of an association with one anti-inflammatory and one gastroprotective agent compared to the one anti-inflammatory and one gastroprotective agent in patients with acute or chronic osteoarticular inflammation.

• Double-blind,randomized, multicenter
• Experiment duration: 14 days
• 03 visits
• Evaluate the safety of an association with one anti-inflammatory and one gastroprotective compared to association with one anti-inflammatory and one gastroprotective agent in patients with acute or chronic osteoarticular inflammation
• Adverse events evaluation

Inclusion Criteria:

• Adults male or female aged ≥ 18 years old;
• Comply with all the purposes and procedures of the study by signing and dating the Informed Consent.
• Acute or chronic osteo-articular injury in need of of anti-inflammatory for a period of 14 days.

Exclusion Criteria:

• Pregnant women, or women in childbearing age who are not in use effective contraception or intending to become pregnant during the study period
• History of peptic ulcer or gastric surgery;
• Use of Non-steroidal anti-inflammatory (NSAIDs), aspirin, proton pump inhibitor (PPIs), H2 blocker and antacid in the past 7 days;
• Contraindication to the use of NSAIDs or PPIs;
• Renal or hepatic impairment;