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The objective of this study is to find a new therapeutic strategy by investigating the serial serum samples of patients with sepsis or postresuscitation state.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Postresuscitation group | Adults (age over 16 years old) who have survived from nontraumatic cardiac arrest and admitted to ICU. | ||
| Sepsis group | Adults (age over 16 years old) who satisfy the sepsis criteria (SIRS>=2 and infection is suspected for a cause) and admitted to the ICU. |
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| Measure | Description | Time Frame |
|---|---|---|
| 1-month mortality | All cause mortality within 1-month | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Hospital mortality | All cause mortality during hospitalization | until hospital discharge, an expected average of 2 weeks |
| ICU length of stay | Until ward transfer or discharge, an expected average of 7 days |
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Inclusion Criteria:
Exclusion Criteria:
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Sepsis patients admitted to ICU Postresuscitation patients admitted to ICU
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kyung Su Kim, MD, PhD | Contact | 82-10-8033-1127 | kanesu@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Gil Joon Suh, Professor | Seoul National University Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Recruiting | Seoul | 110-744 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11445675 | Background | Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001 Jul;29(7):1303-10. doi: 10.1097/00003246-200107000-00002. | |
| 17414736 | Background | Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med. 2007 May;35(5):1244-50. doi: 10.1097/01.CCM.0000261890.41311.E9. |
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| ID | Term |
|---|---|
| D006323 | Heart Arrest |
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
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Patients sera at ICU admission, day-1, day-3 and day-7 are stored in deep freezer.
| Favorable neurologic outcome | Favorable neurologic outcome is used for outcome measure in postresuscitation patients only. Favorable neurologic outcome means cerebral performance category 1 and 2. This outcome is measured at discharge and 6-month after admission. | at discharge, an expected average of 2 weeks and at 6-month |
| 12490963 | Background | Cohen J. The immunopathogenesis of sepsis. Nature. 2002 Dec 19-26;420(6917):885-91. doi: 10.1038/nature01326. |
| 19224811 | Background | Schneider A, Bottiger BW, Popp E. Cerebral resuscitation after cardiocirculatory arrest. Anesth Analg. 2009 Mar;108(3):971-9. doi: 10.1213/ane.0b013e318193ca99. |
| 37878497 | Derived | Kim KS, Suh GJ, Jin M, Kwon WY, Jung YS, Kim T, Kim YT, Kim H, Park H. SECRETED TRYPTOPHANYL-tRNA SYNTHETASE 1 IS A PROGNOSTIC MARKER IN SEPSIS PATIENTS WITHOUT MONOCYTOPENIA. Shock. 2024 Jan 1;61(1):55-60. doi: 10.1097/SHK.0000000000002259. Epub 2023 Oct 20. |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |