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Diastolic function is poorly studied in children with congenital heart disease. This is mainly due to the lack of validated techniques. Cardiac MRI offers two advantages compared to echocardiography: 1. accurate measurements of ventricular volumes and mass; 2. tissue characterization. The main advantage of echocardiography is a better temporal resolution which allows the study of short events like early relaxation. Overall there is a lack of studies correlating different echocardiographic and MRI parameters of heart function in pediatric populations with congenital or acquired heart diseases. This study will address specific questions on specific groups of patients that might bring more insight into chamber interaction and cardiac function. This study hypothesizes the following:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Magnetic Resonance Imaging (MRI) | Experimental | Subjects with congenital heart disease will undergo an echocardiograph, as well as an MRI. |
|
| Echocardiograph | Experimental | Subjects with congenital heart disease will undergo an echocardiograph, as well as an MRI. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Echocardiograph | Procedure |
| ||
| Magnetic Resonance Imaging (MRI) |
| Measure | Description | Time Frame |
|---|---|---|
| Atrial Volumes | Measure right and left atrial volumes by 2D and 3D echo and correlate the different echocardiographic measurements with MRI. This will allow identifying the most accurate measurement which can be used in clinical practice. | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Assess Ventricular Volumes | Assess ventricular volumes and mass and calculate mass/volume ratio. Study the effect of ventricular remodeling on myocardial mechanics especially twisting and untwisting. Relate these changes to evaluation of diastolic function. | Day 1 |
| Myocardial Scarring |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Luc Mertens, MD | Contact | (416)813-7418 | luc.mertens@sickkids.ca |
| Name | Affiliation | Role |
|---|---|---|
| Luc Mertens, MD | The Hospital for Sick Children | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Hospital for Sick Children | Toronto | Ontario | M5G 1X8 | Canada |
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| ID | Term |
|---|---|
| D006330 | Heart Defects, Congenital |
| ID | Term |
|---|---|
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
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| ID | Term |
|---|---|
| D009682 | Magnetic Resonance Spectroscopy |
| ID | Term |
|---|---|
| D013057 | Spectrum Analysis |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
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| Procedure |
|
Assess the presence of myocardial scarring in specific populations with congenital heart disease and correlate the findings with regional and global systolic and diastolic dysfunction. |
| Day 1 |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |