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The true prevalence of drug allergy in patients with a history of beta-lactam hypersensitivity will be determined by using commercially available standard skin test reagents and the diagnostic agents available in Thailand. We hypothesize that only minority of patients with such a history are truly allergic.
Patients with a history of beta-lactam hypersensitivity will be evaluated by the standard skin test reagents (major and minor determinants of penicillin, amoxicillin, and clavulanic if applicable), and intravenous forms of beta-lactam antibiotics .
Diagnostic values of the measurement of specific Immunoglobulin E to penicillin/aminopenicillin and skin test reagents currently available in Thailand will be comparatively analyzed with the standard skin test reagents.
The measurement of drug-induced interferon-gamma releasing cells will be measured in patients with a history of non-immediate reaction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with suspected drug allergy | Patients with a history of hypersensitivity reaction to beta-lactam antibiotics |
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| Measure | Description | Time Frame |
|---|---|---|
| The true prevalence of drug allergy in patients with a history of beta-lactam hypersensitivity | The skin test positive rate in patients with a history of beta-lactam hypersensitivity | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical values of various diagnostic modalities in patients with a history of beta-lactam hypersensitivity | The diagnostic values of skin testing, drug-specific Immunoglobulin E measurement, and interferon-gamma ELISpot assay for the diagnosis of beta-lactam hypersensitivity | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with a history of beta-lactam hypersensitivity
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| Name | Affiliation | Role |
|---|---|---|
| Jettanong Klaewsongkram, MD | Chulalongkorn University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chulalongkorn University | Bangkok | 10330 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36122888 | Derived | Chongpison Y, Palapinyo S, Mongkolpathumrat P, Buranapraditkun S, Thantiworasit P, Klaewsongkram J. Beta-lactam hypersensitivity diagnosis in ambulatory and hospitalized settings require different approaches. Ann Allergy Asthma Immunol. 2023 Jan;130(1):84-92.e1. doi: 10.1016/j.anai.2022.09.011. Epub 2022 Sep 16. |
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| ID | Term |
|---|---|
| D004342 | Drug Hypersensitivity |
| D064420 | Drug-Related Side Effects and Adverse Reactions |
| ID | Term |
|---|---|
| D064419 | Chemically-Induced Disorders |
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Peripheral blood mononuclear cells in patients with a history of non-immediate reaction