Correlation study about Blood Pressure Variability and the prognosis of ischemic stroke with intracranial artery stenosis

Extracranial atherosclerotic stenosis is the main reason for the European and American white ischemic stroke and transient ischemic attack,while Atherosclerotic intracranial arterial stenosis is an important reason for Asian patients with stroke ,accounting for the 33% to 51% of a etiology ratio.The latest research suggests that varying degrees of blood pressure variability can affect the risk of stroke.This study observe the relationship between blood pressure variability and prognosis of ischemic stroke patients with intracranial arterial stenosis,with cranial magnetic resonance imaging (MRI + DWI),magnetic resonance angiography and Trans-cranial Doppler(TCD) .

Inclusion Criteria:

• age : ≥ 18 years of age , ≤ 75 years old
• with intracranial artery stenosis in ischemic stroke
• the diagnosis of ischemic cerebrovascular disease are in line with the diagnostic criteria developed by the Chinese Medical Association Fourth National Cerebrovascular Disease Conference
• the patient admitted to hospital receive at least one examination like cranial MRI + DWI, MRA and TCD examination, clearly associated with intracranial arterial stenosis
• MRS score ≤ 3 points

Exclusion Criteria:

• vascular , cardiac , and unknown causes or other reasons lead to ischemic stroke
• associated with significant emotional disorders, cognitive impairment or other mental disorders can not be partners
• severe occlusion of Unilateral intracranial arteries ( over 90 % ) or bilateral stenosis more than 70%
• With extracranial artery stenosis, especially carotid and vertebral artery stenosis .
• patients with extracranial artery stenosis or patients previously done neck or intracranial artery balloon dilation , stent forming surgery or carotid endarterectomy
• Incomplete clinical data collection in patients