Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Croup is common illness presenting emergency department with dyspnea. The main treatment for croup is nebulized L-epinephrine and steroid. The study for the dose of nebulized L-epinephrine is restricted that the study of comparision between racemic epinephrine and L-epinephrine.
The investigators conducted this study to compare the effectiveness of low dose L-epinephrine with conventional dose L-epinephrine.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| conventional dose epinephrine | Active Comparator | L-epinephrine (1:1000) 0.5 mL/kg (maximum 5mL) + normal saline : total 5mL |
|
| low dose epinephrine | Experimental | L-epinephrine (1:1000) 0.1 mL/kg (maximum 1mL) + normal saline : total 5mL |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| conventional dose epinephrine | Drug | conventional dose epinephrine : 0.5mg/kg + 0.9% normal saline |
|
| Measure | Description | Time Frame |
|---|---|---|
| the difference of Westley croup score between baseline and 30 minutes after neublized treatment | 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| the incidence of use of additional neublized treatment | 30 minutes | |
| Westley croup score | 30, 60, 90, 120, 180, 240 minutes | |
| the side effect of epinephrine |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Recruiting | Seoul | 110-744 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30878411 | Derived | Lee JH, Jung JY, Lee HJ, Kim DK, Kwak YH, Chang I, Kwon H, Choi YJ, Park JW, Paek SH, Cho JH. Efficacy of low-dose nebulized epinephrine as treatment for croup: A randomized, placebo-controlled, double-blind trial. Am J Emerg Med. 2019 Dec;37(12):2171-2176. doi: 10.1016/j.ajem.2019.03.012. Epub 2019 Mar 8. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D003440 | Croup |
| D053120 | Respiratory Aspiration |
| ID | Term |
|---|---|
| D007827 | Laryngitis |
| D007818 | Laryngeal Diseases |
| D012140 | Respiratory Tract Diseases |
| D010038 | Otorhinolaryngologic Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D004837 | Epinephrine |
| ID | Term |
|---|---|
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| low dose epinephrine | Drug | low dose epineprhine : 0.1mg/kg + 0.9% normal saline |
|
Hypertension, tachycardia : more than 95th percentile for age Arrythmia Pallor Tremor |
| participants will be followed for the duration of ED stay |
| respiratory rate, oxygen saturation | 30, 60, 90, 120, 180, 240 minutes |
| health care utilization- length of stay in emergency department, admission rate, revisit dut to croup symptom | within 7 days |
| treatment failure | after additional nebulized epineprhine at 30 minutes, as the croup scrore is higher than baselin, the blinding is cleared. | 30min after 2nd epinephrine nebulizer |
| rebound effect | the croup score is the same or over than the base line | 180 minutes |
| D012120 |
| Respiration Disorders |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D000588 |
| Amines |
| D015306 | Biogenic Monoamines |
| D001679 | Biogenic Amines |
| D002395 | Catecholamines |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |