Pharmacokinetics of Certoparin in Subjects With Renal Insufficiency and Healthy Subjects

An Open-label, Single Center, Parallel-group Study to Compare the Single- and Repeated-dose Pharmacokinetics of Stepwise Increasing Doses of Subcutaneous Certoparin (3000 IU o.d., 3000 IU b.i.d., 8000 IU o.d., and 8000 IU b.i.d.) in Subjects With Severe Renal Insufficiency and Healthy Subjects

This study will assess the pharmacokinetics in subjects with severe renal insufficiency and healthy subjects.

Inclusion criteria:

• Healthy subjects OR
• Subjects with severe renal insufficiency

Exclusion criteria:

• Hypersensitivity to study medication
• Genetic abnormality or disease of clotting system
• Prior major surgery or bleeding
• Other protocol-defined inclusion/exclusion criteria may apply