The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury

The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury

This is a double-blind, placebo-controled, randomized trial to investigate if aspirin pre-treatment has anti-inflammatory effects in a model of acute lung injury induced by inhaled endotoxin (LPS) in healthy human volunteers.

Inclusion Criteria:

• Healthy subjects

Exclusion Criteria:

• Age < 18 years
• Pregnancy or breast feeding or woman of childbearing potential not using
• adequate contraception.
• Participation in a clinical trial of an investigational medicinal product within 30 days
• Consent declined Aspirin or non steroidal anti-inflammatory (NSAID) use in the past 4 weeks
• History of asthma
• Known aspirin or NSAID hypersensitivity
• History of peptic ulcer disease
• Platelet count < 150 x 106/ml
• Aspirin resistance