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| ID | Type | Description | Link |
|---|---|---|---|
| JSPS #18209061 & H19-Choju-008 | Other Grant/Funding Number | JSPS & Ministry of Health, Labor, and Welfare of Japan |
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This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens.
Background: Periodontitis is a prevalent silent infectious disease worldwide, and affects lifestyle-related diseases such as diabetes. Therefore, efficient screening of patients is essential for general health. This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens.
Methods: Oral examination was performed and blood IgG antibody titers against periodontal pathogens were measured by ELISA, in 1387 subjects. The cut-off value of IgG titer was determined in receiver operating characteristic curve analysis, and changes in periodontal clinical parameters and IgG titers by periodontal treatment were evaluated. The relationships between IgG titers and severity of periodontitis were analyzed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| periodontitis | those with periodontitis and those without periodontitis |
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| Measure | Description | Time Frame |
|---|---|---|
| Level of IgG antibodies in serum/plasma against periodontal pathogens | Serum/plasma samples will be screened for the presence of IgG antibodies against the below mentioned periodontal pathogens, using the "ELISA" method. Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Prevotella intermedius, Porphyromonas gingivalis | 1 to 3 months after basic periodontal treatment (Scaling and root planing) |
| Measure | Description | Time Frame |
|---|---|---|
| Periodontal pocket depth | Clinical observation on periodontal pocket depth before and after basic periodontal treatment, in order to confirm appropriate effects of the treatment. | 1 to 3 months after basic periodontal treatment |
| Bleeding on probing |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who visit university hospitals to receive periodontal treatment are patients group.
Employees who receive occupational health check at a company facility.
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| Name | Affiliation | Role |
|---|---|---|
| Shogo Takashiba, Professor | Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Pathiphysiology - Periodontal Science | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aichi Gakuin University, School of Dentistry | Nagoya | Aichi-ken | 4648650 | Japan | ||
| Toyota Motor Corporation |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23018816 | Derived | Kudo C, Naruishi K, Maeda H, Abiko Y, Hino T, Iwata M, Mitsuhashi C, Murakami S, Nagasawa T, Nagata T, Yoneda S, Nomura Y, Noguchi T, Numabe Y, Ogata Y, Sato T, Shimauchi H, Yamazaki K, Yoshimura A, Takashiba S. Assessment of the plasma/serum IgG test to screen for periodontitis. J Dent Res. 2012 Dec;91(12):1190-5. doi: 10.1177/0022034512461796. Epub 2012 Sep 26. |
| Label | URL |
|---|---|
| Introduction site for the project supported by JSPS, and guiding the visitors to "Web-based Management System for Data of Periodontal Infection". Notice: this site is written in Japanese. | View source |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Oct 16, 2012 | |
| Reset | Nov 26, 2012 | |
| Release | May 7, 2013 | |
| Reset | Aug 6, 2013 | |
| Release | Oct 1, 2013 | |
| Reset | Dec 2, 2013 | |
| Release | Apr 20, 2015 | |
| Reset | May 5, 2015 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Oct 16, 2012 | Nov 26, 2012 | |||
| May 7, 2013 |
| ID | Term |
|---|---|
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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plasma and/or serum
Judging from bleeding from gingiva after periodontal pocket probing, degree of inflammation will be understood.
| 1 to 3 monthsafter basic periodontal treatment |
| Tooth mobility | Clinical observation to understand decrease of inflammation | 1 to 3 months after basic periodontal treatment |
| Toyota |
| Aichi-ken |
| 4442225 |
| Japan |
| Nihon University School of Dentistry at Matsudo | Matsudo | Chiba | 2718587 | Japan |
| Hiroshima University Graduate School of Biomedical Sciences | Hiroshima | Hiroshima | 7348553 | Japan |
| Tohoku University Graduate School of Dentistry | Sendai | Miyagi | 9808575 | Japan |
| Nagasaki University Graduate School of Biomedical Sciences | Nagasaki | Nagasaki | 8528588 | Japan |
| Niigata University Faculty of Dentistry | Niigata | Niigata | 9518514 | Japan |
| Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences | Okayama | Okayama-ken | 7008525 | Japan |
| Osaka University Graduate School of Dentistry | Suita | Osaka | 5650871 | Japan |
| The University of Tokushima Graduate School, Institute of Health Biosciences | Tokushima | Tokushima | 7708504 | Japan |
| Tokyo Medical and Dental University Graduate School | Bunkyo-ku | Tokyo | 1138510 | Japan |
| Nippon Dental University, School of Life Dentistry at Tokyo | Chiyoda-ku | Tokyo | 1020071 | Japan |
| Aug 6, 2013 |
| Oct 1, 2013 | Dec 2, 2013 |
| Apr 20, 2015 | May 5, 2015 |