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Rate control in atrial fibrillation is a usual battle in emergency departments. Oral medications have a natural superiority to intravenous ones because they are easy-to-use and decrease the workload in busy emergency departments.
This study wants to find an effective oral medication for rate control in rapid ventricular response atrial fibrillation. Propranolol and Metoprolol, Diltiazem and Verapamil are compared in patients with a stable hemodynamic status.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Metoprolol Per Oral | Experimental | 50 mg Metoprolol |
|
| Verapamil | Experimental | 40 mg Verapamil Per Oral |
|
| Propranolol | Experimental | 40 mg Propranolol Per Oral |
|
| Diltiazem | Experimental | 60 mg Diltiazem Per Oral |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Propranolol | Drug |
|
| |
| Metoprolol |
| Measure | Description | Time Frame |
|---|---|---|
| Rate less than 100 per minute | Ventricular rate less than 100 per minute after 1 hour of per oral medication administration | In 1 hour |
| Measure | Description | Time Frame |
|---|---|---|
| Drugs adverse effects | Drugs adverse effects seen in patients in 2 hours after per oral medication administration | 2 hours |
| Unstability in hemodynamic | Hemodynamic instability (systolic blood pressure less than 90 mmHg, loss of consciousness, pulmonary edema, chest pain) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rasoul-e-Akram Hospital | Tehran | Tehran Province | 14436151 | Iran |
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| ID | Term |
|---|---|
| D011433 | Propranolol |
| D008790 | Metoprolol |
| D014700 | Verapamil |
| D004110 | Diltiazem |
| ID | Term |
|---|---|
| D050198 | Phenoxypropanolamines |
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
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| Drug |
|
|
| Verapamil | Drug |
|
| Diltiazem | Drug |
|
| 2 hours |
| D009930 |
| Organic Chemicals |
| D020005 | Propanols |
| D000588 | Amines |
| D009281 | Naphthalenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D011083 | Polycyclic Compounds |
| D010627 | Phenethylamines |
| D005021 | Ethylamines |
| D001552 | Benzazepines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |