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| Name | Class |
|---|---|
| National Science and Technology Council, Taiwan | OTHER_GOV |
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The purpose of this study will evaluate the long-term benefits, optimal dose and mechanisms of mirror therapy and its effects on physiological markers.
This trial is to examine whether (1) the immediate effects of treatment intensity in MT would occur on sensorimotor impairments and functional performance in patients with subacute stroke; (2) the long-term benefits of treatment intensity in MT on functionality can persist for six months after treatment finished; and (3) the MT could result in cortical/movement reorganization as well as the changes in physiological markers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| mirror therapy treatment | Experimental | Three groups will be involved in this part of the whole project:MT with low-intensity group (MT-LI), MT with moderate-intensity group (MT-MI), MT with high-intensity group (MT-HI) |
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| control intervention group | Active Comparator | The part of this project will involve 1 treatment groups:control intervention group (CI) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MT with low-intensity group (MT-LI) | Behavioral | The MT-LI group will receive a 30-minute MT per session followed by a 30-minute functional training. |
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| Measure | Description | Time Frame |
|---|---|---|
| Fugl-Meyer Assessment (FMA) | The UE subscale of the FMA (max. score 66) uses a 3-point ordinal scale to assess motor impairment. | Baseline, change from baseline in FMA at 2 weeks, and change from baseline in FMA at 4 weeks |
| Action Research Arm Test (ARAT) | ARAT will be used to assess the motor function of UE. A total of 19 items are to test the movement of grasp, grip, pinch, and gross motor, with a scale of 0-3 for each item (maximal of 57). | Baseline, change of ARAT at 2 weeks, and change of ARAT at 4 weeks |
| Motor Activity Log (MAL) | The MAL is a semi-structured interview of patients to assess the amount of use (AOU) and quality of movement (QOM) of the affected upper extremity in 30 important daily activities using a 6-point ordinal scale. Higher scores indicate better performance. | Baseline, change of MAL at 2 weeks, and change of MAL at 4 weeks |
| ABILHAND Questionnaire | ABILHAND questionnaire is an inventory of 56 manual activities that uses a 3-point ordinal scale to measure subjectively perceived difficulty in performing everyday bimanual activity. | Baseline, change of ABILHAND Questionnaire at 2 weeks, and change of ABILHAND Questionnaire at 4 weeks |
| Adelaide Activities Profile (AAP) | AAP will be applied to indicate the level of participation in household and community activities. This profile includes 21 activities in the four areas: domestic chores, household maintenance, service to others, and social activities. | Baseline, change of AAP at 2 weeks, and change of AAP at 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Functional magnetic resonance imaging (fMRI) | uses the blood oxygenation level-dependent (BOLD) response to evaluate the brain reorganization after intervention. | Baseline and change of fMRI at 4 weeks |
| Physiological marker measures |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ching-yi Wu, ScD | Chang Gung University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chang Gung Memorial Hospital | Kwei-shan | Toayuan County | Taiwan |
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| MT with moderate-intensity group | Behavioral | The MT-MI group will receive a 60-minute MT per session followed by a 30-minute functional training. |
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| Mirror therapy with high intensity group | Behavioral | The MT-HI group will receive a 90-minute MT per session followed by a 30-minute functional training |
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| Control intervention group | Behavioral | The CI group will carry out a 30-minute conventional stroke rehabilitation training per session followed by a 30-minute functional training. |
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measure inflammatory markers, oxidative stress markers, and erythrocyte deformability.
| Baseline and change from baseline in physiological marker measures at 4 weeks |
| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D000088762 | Mirror Movement Therapy |
| ID | Term |
|---|---|
| D026741 | Physical Therapy Modalities |
| D012046 | Rehabilitation |
| D013812 | Therapeutics |
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