This study aims to investigate the effectiveness and safety of mesotherapy for the treatment of female pattern alopecia.

• Sixty female subjects between 18 and 65 years diagnosed with female pattern hair loss will undergo mesotherapy sessions weekly for ten weeks.
• One group will receive 0.5%/2ml minoxidil application and a control group will receive application of placebo (saline 0.9%).
• Biopsy of the scalp, trichogram and trichoscopy (Fotofinder) will be performed before and 08 weeks after treatment as a method objective evaluation of the response

This is a trial that aims to analyze the efficacy and safety of mesotherapy with minoxidil 0,5% versus placebo for androgenetic alopecia in female patients.

The patients and the investigators who analyzes complementary exams are blind.

• Clinical criteria, photo, 4mm biopsia, trichogram and trichoscopy are perfomed before patients are randomized into two arms :

  1. Group 1 (Placebo):

     30 patients who will have intradermal injections in the scalp of saline 0.9%

  2. Group 2 (Active Drug):

     30 patients who will receive intradermal injections in the scalp with minoxidil 0.5%/2ml

     Eight weeks after the last session patients will be recruited for repeat the exams and perform a self-assessment of both the effect on hair growth and the effect on hair loss.

Inclusion Criteria:

• Women from 18 to 65 years old
• Androgenetic Alopecia (female pattern hair loss)

Exclusion Criteria:

• patients with alopecia areata or cicatricial alopecia
• pregnancy and breastfeeding
• have undergone any specific treatment in the last 06 months
• use of drugs with anti-androgenic properties
• patients with signs or symptoms of hyper-androgynism