Plasma Cystatin C and Acute Kidney Injury

Use of Cystatin C in Predicting AKI in Patients Undergone Cardiopulmonary Bypass Surgery

To evaluate the utility of plasma cystatin C(pCysC) as a predictive and diagnostic marker of acute kidney injury(AKI) in patients undergone cardiopulmonary bypass surgery.

This is a prospective AKI observational study in patients undergone cardiopulmonary bypass surgery. pCysC and plasma creatine will be measured at entry to ICU.AKI was defined as 50% increase in plasma creatine above baseline.The predictive and diagnostic performance of pCysC will be assessed from area under receiver operator characteristic curve(AUC) and odds ratio(OR).

Inclusion Criteria:

• patients with CPB and admitted to ICU

Exclusion Criteria:

• patients with the age >80 or <18 years
• with preexisting renal dysfunction