The study is to investigate the efficacy and safety of autologous transplantation of adipose-derived mesenchymal stem cells in patients with the sequelae caused by severe brain injury.

Inclusion Criteria:

• Subject has a confirmed diagnosis of a brain AVM (arteriovenous malformation).
• Stroke-like symptoms, including paralysis, caused by brain AVM hemorrhage.
• Subject's modified Rankin scale (mRS) grades IV~V.
• Ages between 20~40 years.
• Estimated life expectancy must be greater than 2 months.
• Signed informed consent from the subject.

Exclusion Criteria:

• Pregnancy test positive.
• Subject infected with hepatitis C, HIV or syphilis.
• Subject not suitable for liposuction surgery.
• Subject not eligible for PET or MRI.
• Subject enrolled in any other cell therapy studies within the past 30 days.
• Subject deemed to be not suitable for the study by the investigator.