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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
| University of Southern California | OTHER |
| University of Toronto | OTHER |
The purpose of this study is to learn about how a woman's health history influences what a normal breast looks like on an MRI. The investigators also want to learn about how the amount of different natural hormones a woman has affects how the breast looks on an MRI. The investigator's hope is that this will help to find women at a high-risk of breast cancer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| premenopausal women | Only women already scheduled for a breast MRI will be included in the study, no additional MRIs will be scheduled for study purposes. |
| |
| postmenopausal women | Only women already scheduled for a breast MRI will be included in the study, no additional MRIs will be scheduled for study purposes. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| questionnaire | Behavioral |
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| Measure | Description | Time Frame |
|---|---|---|
| breast cancer risk factors and background parenchymal enhancement (BPE). | A comparison of the distribution of breast cancer risk factors in women with low and high levels of BPE. The relationship between risk factors and categories of BPE (minimal/mild/moderate/marked) will be determined using ordinal logistic regression. | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| relationship between BPE and serum hormone levels at the time of MRI | Determine the relationship between serum hormone levels (testosterone, estradiol (E2), estrone (E1), androstenedione (A4) and sex hormone binding globulin (SHBG)) at the time of MRI and degree of BPE in healthy high-risk postmenopausal women. The association between circulating serum hormone levels and BPE will be determined using linear regression. |
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Inclusion Criteria:
Exclusion Criteria:
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The proposed study will involve cancer-free women who are undergoing breast MRI screening at MSKCC.
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| Name | Affiliation | Role |
|---|---|---|
| Janice Sung, MD | Memorial Sloan Kettering Cancer Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Memorial Sloan Kettering Cancer Center | New York | New York | 10021 | United States |
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| Label | URL |
|---|---|
| Memorial Sloan Kettering Cancer Center | View source |
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| ID | Term |
|---|---|
| D011795 | Surveys and Questionnaires |
| D055991 | Health Records, Personal |
| D017584 | Reproductive History |
| D000431 | Ethanol |
| D000074602 | Smoking Devices |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
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Blood sample collected at time of MRI for serum hormone analysis Postmenopausal women only
| 1 year |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
| D008499 | Medical Records |
| D011996 | Records |
| D008487 | Medical History Taking |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D015981 | Epidemiologic Factors |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |