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The purpose of this study is to determine the important change in the Short Physical Performance Battery (SPPB) when used in patients with lung disease. The SPPB is a simple physical test that measures balance and the functioning of the legs. It has been widely used in healthy elderly populations and predicts hospital admission and the onset of disability. The SPPB has not previously been used in patients with lung disease, and it is not clear what change in this test is considered meaningful and worthwhile by patients or doctors (the minimal clinically important difference: MID). Knowing what the MID for the SPPB will allow researchers and doctors to evaluate the effectiveness of current and new treatments, and to detect improvement or deterioration in the condition of patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chronic Respiratory Disease | Any patient with a chronic respiratory disease referred for pulmonary rehabilitation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pulmonary rehabilitation | Other | An eight week out-patient based programme consisting of twice weekly supervised exercise and educational sessions |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline of Short Physical Performance Battery | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline of MRC Dyspnoea Scale | 8 weeks | |
| Change from baseline of St George's Respiratory Questionaire | 8 weeks | |
| Anchor question (5-point Likert scale) |
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Inclusion Criteria:
Exclusion Criteria:
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All chronic respiratory disease patients referred for pulmonary rehabilitation.
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| Name | Affiliation | Role |
|---|---|---|
| William DC Man, MRCP, PhD | Repiratory Biomedical Reserach Unit, Royal Brompton & Harefield NHS Foundation Trust and Imperial College London | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Harefield Hospital | Harefield | Middlesex | UB9 6JH | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 1494764 | Background | Singh SJ, Morgan MD, Scott S, Walters D, Hardman AE. Development of a shuttle walking test of disability in patients with chronic airways obstruction. Thorax. 1992 Dec;47(12):1019-24. doi: 10.1136/thx.47.12.1019. | |
| 1595997 | Background | Jones PW, Quirk FH, Baveystock CM, Littlejohns P. A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire. Am Rev Respir Dis. 1992 Jun;145(6):1321-7. doi: 10.1164/ajrccm/145.6.1321. |
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| ID | Term |
|---|---|
| D012140 | Respiratory Tract Diseases |
| D008171 | Lung Diseases |
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Blood taken and stored as whole blood, serum, and plasma.
| 8 weeks |
| 7838189 | Background | Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med. 1995 Mar 2;332(9):556-61. doi: 10.1056/NEJM199503023320902. |
| 28476882 | Derived | Nolan CM, Kon SSC, Patel S, Jones SE, Barker RE, Polkey MI, Maddocks M, Man WD. Gait speed and pedestrian crossings in COPD. Thorax. 2018 Feb;73(2):191-192. doi: 10.1136/thoraxjnl-2017-210173. Epub 2017 May 5. |