Buprenorphine Disposition and Cyclosporine

Influence of Cyclosporine on Buprenorphine Disposition

The determine the effect of cyclosporine on buprenorphine disposition

Subjects studied on four occasions:

1. Intravenous buprenorphine
2. Sublingual buprenorphine
3. Cyclosporine, then intravenous buprenorphine. Subjects then take oral cyclosporine twice daily, until
4. Sublingual buprenorphine; continue oral cyclosporine twice daily for 5 days

Inclusion Criteria:

• 18-50 yr old
• Good general health with no remarkable medical conditions
• BMI < 33
• Provide informed consent

Exclusion Criteria:

• Known history of liver or kidney disease
• Use of prescription or non prescription medications, herbals or foods known to be metabolized by or affecting CYP3A
• Females who are pregnant or nursing
• Known history of drug or alcohol addiction (prior or present addiction or treatment for addiction)
• Direct physical access to and routine handling of addicting drugs in the regular course of duty (a routine exclusion from studies of drugs with addiction potential)