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| Name | Class |
|---|---|
| FUNDACION DEXEUS SALUT DE LA DONA | UNKNOWN |
| Ayudas Merck Serono de Investigación 2012 | UNKNOWN |
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The purpose of this study is to evaluate the clinical pregnancy rate per embryo transfer in oocytes recipients obtained after ovarian stimulation during the luteal phase of oocytes donors . This study will be performed in egg recipients and donors but this type of treatment is meant to be implemented in fertility preservation patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lutheal phase ovarian stimulation | Experimental | Early luteal phase Controlled ovarian hyperstimulation: we will administer in the 13th-15th cycle day simultaneously 0.25 mg/day of ganirelix to induce luteolysis and FSHr (dose according to BMI and AFC )IU/day for controlled ovarian hyperstimulation until achieving criteria for hCG , to induce final oocyte maturation. Mature oocytes will be vitrified. After warming, oocytes will be inseminated by ICSI with the recipients partners semen sample . Recipient endometrium will be primed with estrogen and progesterone , and embryo transfer will be performed on the 3rd day 3 of embryo cleavage. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| gonadotropins plus GnRH antagonists | Drug |
|
| |
| Measure | Description | Time Frame |
|---|---|---|
| Pregnancy rate | six weeks after transfer procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Mature oocytes | Day of oocyte retrieval |
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Inclusion Criteria:
Recipients:
Exclusion Criteria:
-Polycystic ovarian syndrome, gonadotropins allergy
Recipients:
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| Name | Affiliation | Role |
|---|---|---|
| Francisca MartÃnez, PhD | Fundación Dexeus Salut de la Dona | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Departamento de Obstetricia Ginecologia y Reproducción. Institut Universitari Dexeus | Barcelona | Barcelona | 08037 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21292255 | Background | Sonmezer M, Turkcuoglu I, Coskun U, Oktay K. Random-start controlled ovarian hyperstimulation for emergency fertility preservation in letrozole cycles. Fertil Steril. 2011 May;95(6):2125.e9-11. doi: 10.1016/j.fertnstert.2011.01.030. Epub 2011 Feb 3. | |
| 18930226 | Background | von Wolff M, Thaler CJ, Frambach T, Zeeb C, Lawrenz B, Popovici RM, Strowitzki T. Ovarian stimulation to cryopreserve fertilized oocytes in cancer patients can be started in the luteal phase. Fertil Steril. 2009 Oct;92(4):1360-1365. doi: 10.1016/j.fertnstert.2008.08.011. Epub 2008 Oct 18. |
| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D006062 | Gonadotropins |
| D010062 | Ovulation Induction |
| C061018 | ganirelix |
| ID | Term |
|---|---|
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D027724 | Reproductive Techniques, Assisted |
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| ganirelix |
| Drug |
|
|
| 25154677 | Derived | Martinez F, Clua E, Devesa M, Rodriguez I, Arroyo G, Gonzalez C, Sole M, Tur R, Coroleu B, Barri PN. Comparison of starting ovarian stimulation on day 2 versus day 15 of the menstrual cycle in the same oocyte donor and pregnancy rates among the corresponding recipients of vitrified oocytes. Fertil Steril. 2014 Nov;102(5):1307-11. doi: 10.1016/j.fertnstert.2014.07.741. Epub 2014 Aug 22. |
| D012099 | Reproductive Techniques |
| D013812 | Therapeutics |
| D008919 | Investigative Techniques |