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Inability to recruit subjects at our hospital due to change in surgical patient population. Not worth to continue.
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The purpose is to find out if the addition of dexamethasone to ropivacaine 0.5% increases the duration of pain relief provided by popliteal sciatic nerve block performed for foot/ankle surgery. The investigators also want to find out if there is a difference between 4 and 8 mg dose of dexamethasone.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Ropivacaine 0.5% plus 2ml of normal saline used for nerve block |
|
| Dexamethasone 4 mg | Active Comparator | Ropivacaine 0.5% plus 2ml of dexamethasone 4 mg used for nerve block |
|
| Dexamethasone 8 mg | Active Comparator | Ropivacaine 0.5% plus 2ml of dexamethasone 8 mg used for nerve block |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Drug | 2 ml of saline added to 30 ml of ropivacaine 0.5% solution for nerve block |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of analgesia | Duration of analgesia of popliteal fossa sciatic nerve block defined as time of first pain as described by patient minus time of block placement in minutes | 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Total pain medication | Total amounts of morphine, fentanyl and hydrocodone/acetaminophen that the patient required for pain control during first 24 hours after surgery. All patients, regardless of group, will receive a standardized postoperative pain medication regimen which will include hydrocodone/acetaminophen tablets primarily, and morphine/fentanyl as needed. | 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ben Taub General Hospital | Houston | Texas | 77030 | United States |
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| Dexamethasone 4 mg |
| Drug |
2 ml of dexamethasone 4 mg solution added to 30 ml of ropivacaine 0.5% solution for nerve block |
|
| Dexamethasone 8 mg | Drug | 2 ml of dexamethasone 8 mg solution added to 30 ml of ropivacaine 0.5% solution for nerve block |
|
| Pain scores | Pain score measured of numeric analog scale from 0-10 during first 24 hours measures and 0,1,2,4,8,12, and 24 hours after surgery. | 24 hours |
| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D003907 | Dexamethasone |
| ID | Term |
|---|---|
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
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