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Study did not get ethical approval, therefore study was not initiated
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The primary purpose of this study is to identify the effect of meal frequency on blood pressure (BP) levels of individuals.
Migration studies, observational epidemiology and clinical trial data indicate that causes of adverse BP levels are mainly environmental , including lifestyle under which dietary factors play a role. Therefore, lifestyle modification is part of the current American Heart Association recommendations for prevention and control of adverse BP levels.
Although the effects of nutrients and foods on BP have been studied extensively, other dietetic factors such as eating frequency and number of meals in a day have been less thoroughly investigated and warrant further research to explore their possible positive effect on BP.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| low frequency diet | Experimental | Participants will be assigned to a low frequency diet (fixed energy intake) |
|
| High frequency diet | Experimental |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| dietary intervention | Other | a low frequency diet (3 meals/day) a high frequency diet (9 meals/day) |
|
| Measure | Description | Time Frame |
|---|---|---|
| blood pressure | Participants will be asked to wear BP monitor continuously for one week then return it back either by post or bring it themselves to the center. | 2 weeks for 24 hours through blood pressure monitor |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin | biomarkers like: Insulin - Glucose- lipid profile- Free fatty acids- C peptides- HS CRP will be measured regularly during study | measured twice during each phase (2 phases) |
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Inclusion Criteria:
Healthy individuals aged 35-70 years with prehypertension (systolic/diastolic BP 120-139/80-89 mm Hg) BMI 20-30 kg/m2 non-smoking non alcoholic drinkers
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sir John Michael Center - Hammersmith Hospital | London | w2 | United Kingdom |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D004035 | Diet Therapy |
| ID | Term |
|---|---|
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
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