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The investigators will evaluate the efficacy of multi-strain probiotics in adults with diarrhea predominant irritable bowel syndrome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Multi-strain probiotics | Experimental |
| |
| Placebo powder | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Multi-strain probiotics | Drug |
three times a day, within 10 minutes after meal, per oral with water |
| Measure | Description | Time Frame |
|---|---|---|
| change of Irritable bowel syndrome symptom severity score (IBS-SSS) | Severity and frequency of abdominal pain / abdominal bloating / bowel habitus / interfere degree of daily life | after 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Stool frequency and form | Stool frequency (greater than 3 bowel movements/day or less than 3 bowel movements/week) Stool form (lumpy / hard or loose / watery stool) | after 4 weeks and 8 weeks |
| Symptom control of irritable bowel syndrome |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Joo Sung Kim, M.D., PhD | Contact | +82-2-740-8112 | jooskim@snu.ac.kr | |
| Kyoung Sup Hong, M.D. | Contact | +82-10-2578-5738 | kshong1@empas.com |
| Name | Affiliation | Role |
|---|---|---|
| Joo Sung Kim, M.D.,PhD | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Recruiting | Seoul | South Korea |
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| Placebo powder | Drug | same taste, shape, dosage as experimental drug three times a day, within 10 minutes after meal, per oral with water |
|
| after 4 weeks and 8 weeks |
| Improvement of overall symptom in patient with irritable bowel syndrome | after 4 weeks and 8 weeks |
| Assessment for quality of life related with irritable bowel syndrome | after 4 weeks and 8 weeks |
| Assessment for patient satisfaction after administration completion | after 4 weeks and 8 weeks |