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Care for people suffering from depressive symptoms should be given in a step-wise approach. One first step can be the provision of self-help material. Online self-help is an innovative way of providing self-help. The investigators want to study the effect of an interactive online self-help-program (Deprexis) in the treatment of mild to moderate depressive symptoms. Participants will be randomised to either twelve weeks of online-self help or a waiting-list control. Symptoms of depression and other aspects will be assessed over a one year period. Thereafter the controls will also receive online-self help. The investigators hypothesise that online self-help is superior to the control condition in alleviating depressive symptoms and preventing full blown depression.
This study is supported by the German Ministry of Health (BMG) and is a collaborative project of Universität Bern (PD Dr. Thomas Berger), Charité Berlin (PD Dr. Matthias Rose), Universität Bielefeld (Prof. Dr. Wolfgang Greiner), Universität Hamburg (Prof. Dr. Steffen Moritz, Prof. Dr. Bernd Löwe), GAIA AG Hamburg (Dr. Björn Meyer), Universität Tübingen (Prof. Dr. Martin Hautzinger) and Universität Trier (Prof. Dr. Wolfgang Lutz).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Deprexis | Experimental | Online self-help with and without e-mail-support |
|
| Control | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Deprexis | Behavioral | Online self-help with and without e-mail-support |
|
| Measure | Description | Time Frame |
|---|---|---|
| Personal Health Questionnaire (PHQ-9) | 12 wks |
| Measure | Description | Time Frame |
|---|---|---|
| Hamilton Rating Scale for Depression (HRSD) | 12 wks, 6 mths, 12 mths | |
| Quick Inventory of Depressive Symptoms (QIDS) | 12 wks, 6 mths, 12 mths | |
| Personal Health Questionnaire (PHQ-9) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charité Berlin | Berlin | Germany | ||||
| Universität Bielefeld |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24074299 | Background | Klein JP, Berger T, Schroder J, Spath C, Meyer B, Caspar F, Lutz W, Greiner W, Hautzinger M, Rose M, Grafe V, Hohagen F, Andersson G, Vettorazzi E, Moritz S. The EVIDENT-trial: protocol and rationale of a multicenter randomized controlled trial testing the effectiveness of an online-based psychological intervention. BMC Psychiatry. 2013 Sep 28;13:239. doi: 10.1186/1471-244X-13-239. | |
| 27230863 |
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| 6 mths, 12 mths |
| Bielefeld |
| Germany |
| Universität Hamburg | Hamburg | Germany |
| Universität Lübeck | Lübeck | Germany |
| Result |
| Klein JP, Berger T, Schroder J, Spath C, Meyer B, Caspar F, Lutz W, Arndt A, Greiner W, Grafe V, Hautzinger M, Fuhr K, Rose M, Nolte S, Lowe B, Anderssoni G, Vettorazzi E, Moritz S, Hohagen F. Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial. Psychother Psychosom. 2016;85(4):218-28. doi: 10.1159/000445355. Epub 2016 May 27. |
| 33500282 | Derived | Nolte S, Busija L, Berger T, Meyer B, Moritz S, Rose M, Schroder J, Spath-Nellissen C, Klein JP. Do sociodemographic variables moderate effects of an internet intervention for mild to moderate depressive symptoms? An exploratory analysis of a randomised controlled trial (EVIDENT) including 1013 participants. BMJ Open. 2021 Jan 26;11(1):e041389. doi: 10.1136/bmjopen-2020-041389. |
| 31682137 | Derived | Probst T, Berger T, Meyer B, Spath C, Schroder J, Hohagen F, Moritz S, Klein JP. Social phobia moderates the outcome in the EVIDENT study: A randomized controlled trial on an Internet-based psychological intervention for mild to moderate depressive symptoms. J Consult Clin Psychol. 2020 Jan;88(1):82-89. doi: 10.1037/ccp0000441. Epub 2019 Nov 4. |
| 30721109 | Derived | Arndt A, Lutz W, Rubel J, Berger T, Meyer B, Schroder J, Spath C, Hautzinger M, Fuhr K, Rose M, Hohagen F, Klein JP, Moritz S. Identifying change-dropout patterns during an Internet-based intervention for depression by applying the Muthen-Roy model. Cogn Behav Ther. 2020 Jan;49(1):22-40. doi: 10.1080/16506073.2018.1556331. Epub 2019 Feb 5. |
| 29489038 | Derived | Schroder J, Berger T, Meyer B, Lutz W, Spath C, Michel P, Rose M, Hautzinger M, Hohagen F, Klein JP, Moritz S. Impact and change of attitudes toward Internet interventions within a randomized controlled trial on individuals with depression symptoms. Depress Anxiety. 2018 May;35(5):421-430. doi: 10.1002/da.22727. Epub 2018 Feb 28. |
| 28797829 | Derived | Klein JP, Spath C, Schroder J, Meyer B, Greiner W, Hautzinger M, Lutz W, Rose M, Vettorazzi E, Andersson G, Hohagen F, Moritz S, Berger T. Time to remission from mild to moderate depressive symptoms: One year results from the EVIDENT-study, an RCT of an internet intervention for depression. Behav Res Ther. 2017 Oct;97:154-162. doi: 10.1016/j.brat.2017.07.013. Epub 2017 Jul 21. |
| 28710212 | Derived | Klein JP, Gamon C, Spath C, Berger T, Meyer B, Hohagen F, Hautzinger M, Lutz W, Vettorazzi E, Moritz S, Schroder J. Does recruitment source moderate treatment effectiveness? A subgroup analysis from the EVIDENT study, a randomised controlled trial of an internet intervention for depressive symptoms. BMJ Open. 2017 Jul 13;7(7):e015391. doi: 10.1136/bmjopen-2016-015391. |