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The study describes the autonomic control system function in subjects post stroke in comparison with healthy subjects.
Aims: To describe the Autonomic hart rate control system function in post stroke subjects in different rehabilitation levels in comparison with healthy subjects.
To examine the reflective reaction of the autonomic control system as reflected in the heart rate variability to stimulations subjects in different rehabilitation levels in comparison with healthy subjects.
To examine the autonomic control system reaction as reflected in the heart rate variability to physical and cognitive action subjects in different rehabilitation levels in comparison with healthy subjects.
Subjects will be examined 3 times: a week 1 and 3 month post stroke. Control consist similar in description healthy subjects, will be examined once. Each test includes 24 hours Holter surveillance and an examine that include general check that reflects the autonomic reaction to different manipulation.
The examination description:
A. Prior to the examination subjects will be asked to fill the mRS, NIHSS forms.
B. Subjects will receive an examination that includes
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study group 1 | Post hemispheral ischemic stroke cognitively intact. Exclusion: Subjects with severe visual or hearing impairments, stroke location brain steam. The group will be divided in to 4 goups acording to stroke specific location as demonstrated in MRI. | ||
| Control | Control: Healthy subjects resemble in age and sex | ||
| Study -3 | As explained the subjects will be divided into 4 groups acording to the stroke location. this is in order to evaluat the relationship between location and autonomic responed. | ||
| Stydy -2 | As explained the subjects will be divided into 4 groups acording to the stroke location. this is in order to evaluat the relationship between location and autonomic responed. | ||
| Stydy- 4 | As explained the subjects will be divided into 4 groups acording to the stroke location. this is in order to evaluat the relationship between location and autonomic responed. |
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| Measure | Description | Time Frame |
|---|---|---|
| RMSSD change | The root mean square successive difference (RMSSD) in heart period series is a time domain measure of heart period variability. we will follow up the change in RMSSD at 1st and 3rd month post stroke | 3 month post stroke |
| Measure | Description | Time Frame |
|---|---|---|
| 6mwt | Endurance will be measured with the 6 minute walk test (6MWT). we will follow up the endurane change. | 3 month post stroke |
| Patient's characteristics | a. Patient's characteristics questionnaire will include data such as: age, gender, health condition, medication, habits, education, etc. B. mRS and NIHSS questionears |
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Inclusion Criteria:
Exclusion Criteria:
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Post hemispheral ischemic stroke cognitively intact.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Natan Borshtain, prof. | Contact | 972-3-6973159 | ||
| Noa Raphaely Beer, Mrs. | Contact | 972-52-8898918 | raphaelybeer@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Nathan Borshtin, Prof. | Tel Aviv Suraski medical center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tel Aviv Souraski Medical Center Neurology department | Tel Aviv | Israel |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| 3 month post stroke |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |