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Antidepressants are among the most widely prescribed medications, yet only 35-45% of patients achieve remission following an initial antidepressant trial. The financial burden of treatment failures in direct treatment costs, disability, decreased productivity, and missed work may in part derive from a mismatch between optimal, and actual, medications prescribed. The present one year retrospective study seeks to evaluate the indirect and direct healthcare costs for 96 patients with a DSM-IV-TR depressive or anxiety disorder, in relation to an interpretive reporting system designed to predict antidepressant responses based on DNA variations in cytochrome P450 genes (CYP2D6, CYP2C19, CYP1A2), the serotonin transporter gene (SLC6A4), and the serotonin 2A receptor (5HTR2A) genes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Depression and anxiety | Subjects with a primary diagnosis of depression or anxiety disorder. |
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| Measure | Description | Time Frame |
|---|---|---|
| Number of Outpatient Visits | Number of outpatient healthcare visits during study window | During the one year study window (April 1, 2010 to April 1, 2011) |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Medical Absence Days | Number of medical absence days during study window | During the one year study window (April 1, 2010 to April 1, 2011) |
| Number of Disability Claims | Number of disabiity claims during study window |
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Inclusion Criteria:
Exclusion Criteria:
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Subjects under the care of a psychiatrist at Union Health Services, Chicago, IL
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| Name | Affiliation | Role |
|---|---|---|
| Aida Spahic-Mihajlovic, MD | Union Health Services | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Union Health Services | Chicago | Illinois | 60612 | United States |
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| ID | Title | Description |
|---|---|---|
| FG000 | Depression and Anxiety | Subjects with a primary diagnosis of depression or anxiety disorder. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Depression and Anxiety | Subjects with a primary diagnosis of depression or anxiety disorder. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Number of Outpatient Visits | Number of outpatient healthcare visits during study window | Posted | Mean | Standard Deviation | units on a scale | During the one year study window (April 1, 2010 to April 1, 2011) |
|
|
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Depression and Anxiety | Subjects with a primary diagnosis of depression or anxiety disorder. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Joel Winner, MD | AssureRx | 513-234-0510 | jwinner@assurerxhealth.com |
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| ID | Term |
|---|---|
| D003863 | Depression |
| D001008 | Anxiety Disorders |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D001523 | Mental Disorders |
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Buccal samples
| During the one year study window (April 1, 2010 to April 1, 2011) |
| Participants |
|
| Age, Continuous | Mean | Standard Deviation | years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
|
| Secondary | Number of Medical Absence Days | Number of medical absence days during study window | Not Posted | During the one year study window (April 1, 2010 to April 1, 2011) |
| Secondary | Number of Disability Claims | Number of disabiity claims during study window | Not Posted | During the one year study window (April 1, 2010 to April 1, 2011) |
| 0 |
| 104 |
| 0 |
| 104 |
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