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| ID | Type | Description | Link |
|---|---|---|---|
| DRKS00004197 | Registry Identifier | Deutsches Register Klinischer Studien | |
| 01GI1127 | Other Grant/Funding Number | Bundesministerium für Bildung und Forschung | |
| U1111-1131-8145 | Other Identifier | overall project: Medical & psychosoc. implications of adolescent extr. obesity, acceptance & effects of structured care |
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| Name | Class |
|---|---|
| University of Witten/Herdecke | OTHER |
| Charite University, Berlin, Germany | OTHER |
| University of Leipzig | OTHER |
| Universität Duisburg-Essen |
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Obesity is one of the biggest public health challenges today and in the years to come, particularly due to its rising prevalence in children and adolescents. In addition to the increased health risks for each individual, obesity causes a tremendous economic burden on the healthcare system.
Here, the investigators will examine the impact of extreme obesity on healthcare utilization, costs, and health related quality of life in adolescents. The study is a subproject of the "Medical and psychosocial implications of adolescent extreme obesity - acceptance and effects of structured care study", short: "Youth with Extreme obesity Study (YES)", which aims at improving the medical care and social support structures for youth with obesity and extreme obesity in Germany. Obese youth and young adults (BMI ≥ 30kg/m2) between the ages of 14 and 24.9 years (initially up to 21 years) are eligible to participate. Participants will complete questionnaires to assess health related quality of life and utilization of healthcare. These questionnaires will be applied at baseline and then every 12 months (initially every 6 months) during health check-ups. As part of the other subprojects of YES, participants will be invited to complete further questionnaires and will be offered a thorough medical examination, medical care and psycho-social support.
The investigators expect to provide valid and up-to-date information on costs and health-related quality of life for obese adolescents. This information will help in the planning of useful and cost effective preventive and therapeutic strategies, and improve the medical care and support structures for obese adolescents.
Obesity is acknowledged as one of the biggest public health challenges today and in the years to come, particularly due to its rising prevalence in children and adolescents. In addition to the physical, mental and social health consequences of the obesity epidemic, a major concern that emanates from overweight and obesity is the related economic burden. Here, the investigators will invexamine the impact of extreme obesity (BMI ≥35kg/m2) on healthcare utilization, costs, and health related quality of life in a cohort of adolescents. Adolescents with more moderate obesity (BMI 30-34.9kg/m2) will serve as a control group. The study is a subproject of the "Medical and psychosocial implications of adolescent extreme obesity - acceptance and effects of structured care", short: "Youth with Extreme obesity Study (YES)", which comprises the recruitment and characterization of obese (BMI 30-34.9kg/m2) and extremely obese (BMI ≥35kg/m2) youth from different healthcare- and non healthcare settings, a randomized controlled trial to investigate a novel intervention targeted at improving quality of life and social functioning of extremely obese adolescents, a structured prospective evaluation of adolescent bariatric surgery, and a long-term prospective observation study.
Based on the current state of knowledge, the investigators have formulated the following hypotheses in regards to healthcare utilization, costs, and health related quality of life:
A total of 600 adolescents age 14 to 24.9 years (initially up to 21 years) with extreme obesity (BMI ≥ 35 kg/m2) and 600 adolescents with obesity (BMI 30-34.9 kg/m2) will be recruited over a 24 months period. The five participating university centers are distributed across 4 geographic regions in the North (Berlin), in the West (Essen/Datteln), in the East (Leipzig) and in the South (Ulm) of Germany, and will therefore render data that are representative of Germany as a whole.
Utilization and healthcare costs associated with extreme obesity in adolescents will be assessed via standardized patient questionnaires. Health related quality of life associated with extreme obesity in adolescents will be assessed with validated instruments at baseline and then every 12 months (initially every 6 months). Cost-effectiveness and cost-utility analyses will be performed.
The investigators expect to provide valid and up-to-date information on healthcare costs and health-related quality of life for this relevant patient group. This information will inform the planning of future preventive and therapeutic strategies.
In February 2013, an amendment was added to the study to include patients up till 24.9 years. In addition, in an amendment in December 2014, the number of visits was reduced from biannually to annually and a travel-imbursement of 30€ for the patients was implemented.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| extremely obese | BMI ≥35kg/m2 | ||
| obese | BMI 30-34.9kg/m2 |
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| Measure | Description | Time Frame |
|---|---|---|
| Economic burden of extreme obesity in adolescents living in Germany | Resource utilization and calculate health care cost will be elicited using a standardized patient questionnaire that was developed and tested by the Helmholtz Zentrum München. | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Health related quality of life associated with extreme obesity in adolescents | Health related quality of life will be elicited via validated patient questionnairs (EQ5D, DISABKIDS). | at baseline and every 12 months |
| BMI |
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Inclusion Criteria:
Exclusion Criteria:
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Subjects will be recruited from the general population through different healthcare- and non healthcare settings to ascertain the inclusion of treatment-seeking and non treatment-seeking individuals. Healthcare settings include university based obesity clinics, physician offices and health insurance agencies. Non-healthcare settings include schools, job centers, and employment agencies.
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| Name | Affiliation | Role |
|---|---|---|
| Martin Wabitsch, Prof. Dr. med. | University of Ulm | Principal Investigator |
| Susanna Wiegand, Dr. med. | Charite University, Berlin, Germany | Principal Investigator |
| Thomas Reinehr, Prof. Dr. med. | University of Witten/Herdecke | Principal Investigator |
| Johannes Hebebrand, Prof. Dr. med. | Universität Duisburg-Essen | Principal Investigator |
| Wieland Kiess, Prof. Dr. med. | University of Leipzig | Principal Investigator |
| Reinhard Holl, Prof. Dr. med. | University of Ulm | Principal Investigator |
| Rolf Holle, Prof. Dr. | Helmholz Center Munich | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ambulatory Obesity Program, Charité University, Berlin | Berlin | 13353 | Germany | |||
| Vestische Kinderklinik, University of Witten/Herdecke |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23987123 | Derived | Wabitsch M, Moss A, Reinehr T, Wiegand S, Kiess W, Scherag A, Holl R, Holle R, Hebebrand J. Medical and psychosocial implications of adolescent extreme obesity - acceptance and effects of structured care, short: Youth with Extreme Obesity Study (YES). BMC Public Health. 2013 Aug 29;13:789. doi: 10.1186/1471-2458-13-789. |
| Label | URL |
|---|---|
| study homepage | View source |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D009767 | Obesity, Morbid |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| OTHER |
| Helmholtz Zentrum München | INDUSTRY |
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weight in kg divided by height squared in meters
| at baseline and every 12 months |
| Changes in economic burden of extreme obesity in adolescents living in Germany | Resource utilization and calculate health care cost will be elicited using a standardized patient questionnaire that was developed and tested by the Helmholtz Zentrum München. | every 12 months |
| Datteln |
| Germany |
| University Duisburg-Essen | Essen | 45147 | Germany |
| University Hospital Leipzig | Leipzig | 04103 | Germany |
| Dept for Pediatrics and Adolescent Medicine, University of Ulm: Interdisciplinary obesity clinic | Ulm | 89075 | Germany |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |