Levothyroxine for Children With Euthyroid Sick Syndrome

Efficacy and Safety of Levothyroxine in Critical Children With Euthyroid Sick Syndrome in a Pediatric Intensive Care Unit.

The purpose of this study is to determine whether levothyroxine is effective and safe in the treatment of children with euthyroid sick syndrome, hospitalized in a pediatric intensive care unit.

Children with euthyroid sick syndrome, hospitalized in a pediatric intensive care unit, will be randomised to receive either Levothyroxine or placebo, to determine if it diminishes mortality.

Inclusion Criteria:

• All children aged 1 month to 17 years.
• Admitted to pediatric intensive care unit.
• TSH and thyroid hormones below age specific levels.

Exclusion Criteria:

• Known thyroid condition.
• Brain death.
• Gut conditions that contraindicate oral route.
• Readmissions to intensive care unit.