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The purpose of this study is to determine if a recruitment maneuver combined with protective ventilatory strategy could reduce the pulmonary and systemic inflammatory responses to one-lung ventilation during thoracic surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| conventional | No Intervention | Two-lung ventilation: tidal volume = 10 ml/kg, no PEEP. One-lung ventilation: tidal volume = 10 ml/kg, no PEEP | |
| Protective | Active Comparator | Two-lung ventilation: tidal volume 8 ml/kg, PEEP of 5 cmH2O. One-lung ventilation: tidal volume 6 ml/kg, PEEP of 5 cmH2O. |
|
| Recruitment | Active Comparator | Two-lung ventilation: tidal volume 8 ml/kg, PEEP of 5 cmH2O. One-lung ventilation: tidal volume 6 ml/kg, PEEP of 5 cmH2O. Recruitment maneuver will be applied during one-lung ventilation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| protective ventilation | Procedure | low tidal volume and PEEP |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Levels of IL-8, TNFa in the bronchoalveolar lavage | up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Levels of IL-1, IL-6, IL-10 in the bronchoalveolar lavage | up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery | |
| plasmatic concentration of inflammatory mediators IL-1, IL-6, IL-8, IL-10, TNFa | up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | South Korea |
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| Recruitment maneuver combined with protective ventilation |
| Procedure |
Low tidal volume, PEEP and recruitment maneuver |
|
| oxygenation | Changes in PaO2/FIO2 ratio | 1 hour after extubation |
| Chest-X ray | 7 days after surgery |
| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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