Vascular Impairment in Type II Diabetes Mellitus With Co-morbid Obstructive Sleep Apnea

Vascular Impairment in Type II Diabetes Mellitus With Co-morbid Obstructive Sleep Apnea.

The investigators will examine the possible synergistic effects of obstructive sleep apnea (OSA) and type II diabetes mellitus (DM) on vascular functioning by performing a two-part investigation:

• A cross-sectional study comparing subjects with OSA+DM, OSA only, DM only, and healthy controls.
• A three-month randomized placebo-controlled trial of continuous positive airway pressure (CPAP) in subjects with OSA+DM.

Inclusion Criteria:

• OSA subjects: apnea-hypopnea index >=10 and <100
• DM subjects: clinical diagnosis of DM and glycated hemoglobin < 8.0%

Exclusion Criteria:

• Hematocrit < 32
• Pregnancy
• Infectious/collagen vascular/hepatic or renal/cardiopulmonary disease