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| Name | Class |
|---|---|
| University of Iowa | OTHER |
| Christiana Care Health Services | OTHER |
| University of Cincinnati | OTHER |
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Despite its life-saving potential, the mechanical ventilator has great potential to do harm. Despite years of research, the mortality in acute lung injury (ALI) remains very high. Treatment options after ALI onset are very limited, therefore prevention may be the best option. Unfortunately, the emergency department has not been studied with respect to mechanical ventilation practices, and its contribution to ALI is unknown. The investigators hypothesize that mechanical ventilation is frequently used in the ED and for a variety of reasons, and that ED mechanical ventilation has an effect on long term outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| All ED patients requiring mechanical ventilation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| For inclusion in the study, patients will have to require mechanical ventilation either via an endotracheal tube or tracheostomy tube. | Other | Mechanical ventilation via an endotracheal tube or tracheostomy tube |
| Measure | Description | Time Frame |
|---|---|---|
| To Further Characterize ED Mechanical Ventilation | In a prospective cross-sectional study design, we will enroll all patients receiving mechanical ventilation in the ED over a one-month time frame. | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| The Incidence of ARDS in Mechanically Ventilated Emergency Department Patients, and Risk Factors Associated With Progression to ARDS | Development of ARDS after admission to the hospital | 1 month |
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Inclusion Criteria:
Exclusion Criteria:
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Patients presenting to the emergency department requiring invasive mechanical ventilation.
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| Name | Affiliation | Role |
|---|---|---|
| Brian M Fuller, MD | Washington University School of Medicine in St. Louis | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Christiana Care Health System | Newark | Delaware | 19718 | United States | ||
| University of Iowa College of Medicine |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25742126 | Derived | Fuller BM, Mohr NM, Miller CN, Deitchman AR, Levine BJ, Castagno N, Hassebroek EC, Dhedhi A, Scott-Wittenborn N, Grace E, Lehew C, Kollef MH. Mechanical Ventilation and ARDS in the ED: A Multicenter, Observational, Prospective, Cross-sectional Study. Chest. 2015 Aug;148(2):365-374. doi: 10.1378/chest.14-2476. |
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| ID | Title | Description |
|---|---|---|
| FG000 | All ED Patients Requiring Mechanical Ventilation | Assessed for mechanical ventilation parameters, predictors of ARDS in the patients without ARDS in the ED (n=204), and outcome differences between all patients with ARDS (n=45) and those not progressing to ARDS (n= 174). These 45 patients includes the 15 patients with ARDS in the ED and the 30 participants with incident ARDS after ED admission. |
| Title | Milestones | Reasons Not Completed | |||||
|---|---|---|---|---|---|---|---|
| Overall Study |
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| Iowa City |
| Iowa |
| 52242 |
| United States |
| Washington University School of Medicine | St Louis | Missouri | United States |
| University of Cincinnati College of Medicine | Cincinnati | Ohio | United States |
| COMPLETED |
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| NOT COMPLETED |
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| ID | Title | Description |
|---|---|---|
| BG000 | Entire Cohort | Characteristics of mechanically ventilated ED patients |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age, Customized | Mean | Standard Deviation | years |
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| Sex: Female, Male | Count of Participants | Participants |
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| Race/Ethnicity, Customized | Number | participants |
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| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | To Further Characterize ED Mechanical Ventilation | In a prospective cross-sectional study design, we will enroll all patients receiving mechanical ventilation in the ED over a one-month time frame. | Tidal volume used for the entire cohort | Posted | Median | Inter-Quartile Range | mL | 1 month |
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| Secondary | The Incidence of ARDS in Mechanically Ventilated Emergency Department Patients, and Risk Factors Associated With Progression to ARDS | Development of ARDS after admission to the hospital | Posted | Number | participants | 1 month |
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Patients were enrolled for a month and followed until death or hospital discharge.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | All ED Patients Requiring Mechanical Ventilation | For inclusion in the study, patients will have to require mechanical ventilation either via an endotracheal tube or tracheostomy tube.: Mechanical ventilation via an endotracheal tube or tracheostomy tube | 72 | 219 | 0 | 219 | 0 | 219 |
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This was an observational study, so only associations (and not causation) can be concluded from the data.
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Brian M Fuller | Washington University in St. Louis | 3147475368 | fullerb@wusm.wustl.edu |
| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| D055371 | Acute Lung Injury |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D055370 | Lung Injury |
| D008171 | Lung Diseases |
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| other |
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