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| Name | Class |
|---|---|
| Ministry of Health, France | OTHER_GOV |
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The purpose of this study is to determine whether acetazolamide are effective to reduce the length of mechanical ventilation in decompensated Chronic Obstructive Pulmonary Disease (COPD) patients developing pure or mixed metabolic alkalosis.
The purpose of this study is to determine whether acetazolamide is effective to reduce the length of mechanical ventilation in decompensated COPD patients developing pure or mixed metabolic alkalosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acetazolamide | Active Comparator | Acetazolamide (1 g IV per day or 2 g IV per day if coprescription of loop diuretics) or Placebo (saline serum) when pure or mixed metabolic alkalosis being present until planned extubation |
|
| Placebo | Placebo Comparator | Placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acetazolamide | Drug | Acetazolamide (1 g IV per day or 2 g IV per day if coprescription of loop diuretics) or Placebo (saline serum) when pure or mixed metabolic alkalosis being present until planned extubation |
| Measure | Description | Time Frame |
|---|---|---|
| length of invasive mechanical ventilation | within the first 28 days after intubation |
| Measure | Description | Time Frame |
|---|---|---|
| Length of weaning from mechanical ventilation | data retrieved once, at the extubation or at the end of invasive ventilation in the tracheotomy | once at the extubation or at day 28 |
| weaning success |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Christophe Faisy, MD, PhD | Medical Intensive Care Unit, European Georges Pompidou Hospital, Asssistance Publique - Hôpitaux de Paris, Paris Descartes University, Paris, FRance | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinical Research Unit, European Georges Pompidou Hospital, Assistance Publique - Hôpitaux de Paris | Paris | 75015 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21917139 | Background | Heming N, Faisy C, Urien S. Population pharmacodynamic model of bicarbonate response to acetazolamide in mechanically ventilated chronic obstructive pulmonary disease patients. Crit Care. 2011;15(5):R213. doi: 10.1186/cc10448. Epub 2011 Sep 14. | |
| 20217 | Background | Chang WT, Thayer DW. The cellulase system of a Cytophaga species. Can J Microbiol. 1977 Sep;23(9):1285-92. doi: 10.1139/m77-192. |
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| Placebo | Drug | Placebo |
|
Data collected once at the end of ICU stay or at Day 28
| once at the end of ICU stay or at Day 28 |
| numbers of nosocomial infections | data retrieved every day, until extubation or at the end of invasive ventilation in the tracheotomy | every day during 28 days |
| length of ICU stay | Data collected once at the end of ICU stay or at Day 28 | once at the end of ICU stay or at Day 28 |
| ICU mortality | Data collected once at the end of ICU stay or at Day 28 | once at the end of ICU stay or at Day 28 |
| 26836730 | Derived | Faisy C, Meziani F, Planquette B, Clavel M, Gacouin A, Bornstain C, Schneider F, Duguet A, Gibot S, Lerolle N, Ricard JD, Sanchez O, Djibre M, Ricome JL, Rabbat A, Heming N, Urien S, Esvan M, Katsahian S; DIABOLO Investigators. Effect of Acetazolamide vs Placebo on Duration of Invasive Mechanical Ventilation Among Patients With Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial. JAMA. 2016 Feb 2;315(5):480-8. doi: 10.1001/jama.2016.0019. |
| ID | Term |
|---|---|
| D000086 | Acetazolamide |
| ID | Term |
|---|---|
| D013830 | Thiadiazoles |
| D013844 | Thiazoles |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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