Integrated Dose Escalation for Advanced, Localized Gynecologic Cancer (The IDEAL - GYN Trial)

Integrated Dose Escalation for Advanced, Localized Gynecologic Cancer (The IDEAL - GYN Trial)

The purpose of this study is to determine the maximum tolerated dose of integrated boost radiation therapy when given with concurrent chemotherapy (cisplatin).

Inclusion Criteria:

• Biopsy confirmed malignancy of the gynecologic tract
• Involved pelvic or para-aortic lymph nodes
• Treatment plan to include delivery of concurrent chemoradiotherapy.
• Good performance status
• Negative pregnancy test in women of child-bearing potential
• Signed study-specific informed consent
• Lab results within study specific limits

Exclusion Criteria:

• Prior radiation to the abdomen or pelvis
• A history of Scleroderma or Inflammatory bowel disease
• Contraindication to chemotherapy or radiation