Continuous Regional Arterial Infusion of Low Molecular Weight Heparin in Patients With Severe Acute Pancreatitis

Our animal studies found that continuous regional arterial infusion (CRAI in the celiac trunk) of low molecular weight heparin (LMWH) could alleviate inflammation, improve global hemodynamics and restore organ function in a porcine model of severe acute pancreatitis (SAP,unpublished).

In this study, the investigators aim to evaluate the effects of CRAI of LMWH in the treatment of SAP patients. The investigators suppose CRAI could help improve the outcomes of these patients.

Inclusion Criteria:

• Symptoms and signs of severe acute pancreatitis according to Atlanta criteria
• Within 3 days from the onset of the disease
• Available for interventional treatment(not sensible to radiocontrast agent)

Exclusion Criteria:

• Pregnant pancreatitis
• Receiving surgery or aspiration before;need of early surgery
• Patients with coagulation disorders