Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Our animal studies found that continuous regional arterial infusion (CRAI in the celiac trunk) of low molecular weight heparin (LMWH) could alleviate inflammation, improve global hemodynamics and restore organ function in a porcine model of severe acute pancreatitis (SAP,unpublished).
In this study, the investigators aim to evaluate the effects of CRAI of LMWH in the treatment of SAP patients. The investigators suppose CRAI could help improve the outcomes of these patients.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CRAI | Experimental | CRAI of LMWH in the celiac trunk |
|
| Conservative treatment | Other | Conservative treatment without CRAI, control group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Continuous regional arterial infusion of low molecular weight heparin in celiac trunk | Procedure | Put a catheter to the celiac trunk through interventional technique. The approach to celiac trunk was via a femoral artery approach.The tip of the arterial catheter (4F) was placed in celiac trunk which could perfuse the pancreas.After that, continuous infusion of low molecular weight heparin through the catheter will be applied during the first 5 days after placement. |
| Measure | Description | Time Frame |
|---|---|---|
| coagulation related complications | bleeding for the most coagulative parameters | 14 days after the placement of celiac trunk catheter |
| Pancreatic infection | 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| pancreatic necrosis | 28 days | |
| ICU duration | Participants will be followed until the date of discharge from the ICU,assessed up to 6 weeks. Patients who die during hospitalization are excluded from this measurement. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Weiqin Li, Dr | Contact | +86-025-80860066 | kkb9832@gmail.com | |
| Zhihui Tong, Dr | Contact | +86-025-80860066 | njzyantol@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Weiqin Li, Dr | Jinling Hospital, School of Medicine, Nanjing University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of SICU, Research Institute of General Surgery Jinling Hospital, Nanjing, Jiangsu, China | Recruiting | Nanjing | Jiangsu | 210002 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20104197 | Background | Lu XS, Qiu F, Li YX, Li JQ, Fan QQ, Zhou RG. Effect of lower-molecular weight heparin in the prevention of pancreatic encephalopathy in the patient with severe acute pancreatitis. Pancreas. 2010 May;39(4):516-9. doi: 10.1097/MPA.0b013e3181c3c954. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| General treatment | Other | Include fluid resuscitation, percutaneous drainage if needed, antibiotics,organ support, etc. |
|
| Hospital duration | Participants will be followed until the date of discharge from the hospital,assessed up to 3 months. Patients who die during hospitalization are excluded from this measurement. |
| Mortality | Participants will be followed until the date of discharge or the date of death from any cause, whichever came first, assessed up to 3 months |
| ID | Term |
|---|---|
| D010195 | Pancreatitis |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
Not provided
Not provided