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To access the clinical usefulness of F1+2 in the diagnosis of PE in patients with AECOPD who require hospitalization. Specifically, to determine whether F1+2 may have an additional value in the subgroup of patients with an abnormal D-dimer,to determine whether it may increase the proportion of patients in whom PE can be safely ruled out and to determine the sensitivity, specificity and NPV of F1+2 at various cut-off values.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COPD Exacerbation | Patients admitted to hospital with COPD exacerbation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CT pulmonary angio, blood tests | Other | CT pulmonary angiography to determine PE and laboratory blood tests to determine prothrombin fragments F1+2 in blood of COPD patients |
|
| Measure | Description | Time Frame |
|---|---|---|
| Negative Predictive Value of Prothrombin Fragment F1+2 | Blood test to determine predictive value of Prothrombin Fragment F1+2 in PE diagnosis in hospitalized COPD patients | Six months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients admitted to hospital due to COPD exacerbation
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ihab Abdelhai, MD | Contact | 972-4-630-4525 | ihababdelhai69@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hillel Yaffe Medical Center | Hadera | 38100 | Israel |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D011655 | Pulmonary Embolism |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D004617 | Embolism |
| D016769 | Embolism and Thrombosis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D006403 | Hematologic Tests |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
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