Measurement of Eye Blood Flow and Renal Function in Healthy and Diabetic Patients

Eye Blood Flow and the Kidney

The purpose of this study is to the determine the effect of salt intake and Captopril on the ophthalmic artery (OA) blood supply of individuals with Type 2 Diabetes Mellitus.

The overall objective of this study is to ascertain if salt intake affects ophthalmic artery (OA) blood flow. In addition, we will study both the eye and kidney response to ACE inhibition compared to placebo while controlling salt intake in subjects with Type 2 diabetes mellitus.

We hypothesize that salt intake will affect OA blood flow.

We will initially look at both eye and renal response to subjects on a low salt diet (10mEq Na/day) followed by response to high salt diet (200mEq Na/day). In addition, we may look at eye response while subjects consume their regular diet.

Inclusion Criteria:

• Type 2 Diabetes Mellitus

Exclusion Criteria:

• Type 1 Diabetes Mellitus
• Heart Attack or Stroke within the last 6 months
• Pregnant or lactating females