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| ID | Type | Description | Link |
|---|---|---|---|
| NCI-2012-01976 | Registry Identifier | CTRP (Clinical Trial Reporting Program) | |
| CDR0000735342 | Other Identifier | Clinical Trials.gov | |
| COG-AALL12B7 | Other Identifier | Children's Oncology Group |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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This laboratory study is looking into genes in samples from younger patients with relapsed acute lymphoblastic leukemia. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer.
OBJECTIVES:
I. To identify global changes in the epigenome and various underlying histone modifications that characterize relapsed acute lymphoblastic leukemia (ALL).
II. To identify specific transcription factor-binding sites associated with histone alterations.
III. To correlate gene expression changes of differentially regulated genes at relapse with underlying chromatin modifications.
OUTLINE:
Archived bone marrow samples, collected at the time of diagnosis and relapse, are analyzed for gene expression and histone modifications by microarray, chromatin immunoprecipitation (ChIP) sequencing, and quantitative real-time polymerase chain reaction (qRT-PCR).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Observational | Archived bone marrow samples, collected at the time of diagnosis and relapse, are analyzed for gene expression and histone modifications by microarray, chromatin immunoprecipitation (ChIP) sequencing, and quantitative real-time polymerase chain reaction (qRT-PCR). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| laboratory biomarker analysis | Other | Correlative studies |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cellular origins of relapse and the underlying epigenetic mechanisms associated with drug resistance | 1 month | |
| Genes associated with histone modification | 1 month | |
| Biological pathways involved in relapse | 1 month |
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Inclusion Criteria:
Diagnosis of B-cell acute lymphoblastic leukemia
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Diagnosis of B-cell acute lymphoblastic leukemia
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| Name | Affiliation | Role |
|---|---|---|
| William Carroll, MD | Children's Oncology Group | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Children's Oncology Group | Arcadia | California | 91006-3776 | United States |
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Archived bone marrow samples
| ID | Term |
|---|---|
| D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
| ID | Term |
|---|---|
| D007945 | Leukemia, Lymphoid |
| D007938 | Leukemia |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
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