Agreement Between Arterial, Central Venous, and Peripheral Venous Lactate in the Intensive Care Unit

Agreement Between Arterial, Central Venous, and Peripheral Venous Lactate in the Intensive Care Unit

The main objective of this study is to examine the agreement between arterial, central venous, and peripheral venous lactate values in a population of medical Intensive Care Unit (ICU) patients.

This study is a single-center, prospective trial to assess the agreement between arterial, central venous, and peripheral venous lactate measurements. When an arterial lactate is deemed to be necessary as part of ICU management, a central venous and peripheral venous sample will also obtained within 5 minutes. All of the samples will be analyzed using the same analyzer as quickly as possible. A maximum of 10 paired arterial and venous lactate samples will be obtained per patient to prevent a single patient from dominating the data set. Additional data collected on a standardized data collection form will include primary diagnosis, intubation status, use of inotropic agents, hypotension (defined as a systolic blood pressure < 90 mm Hg), ICU length of stay and mortality. The Bland-Altman method will be used to assess agreement between arterial (A), central venous(CV), and peripheral venous (PV) lactate measurements. Approximately 50 patients will be enrolled in this study.

Inclusion Criteria:

• Adult patients 18 years or older
• Admitted to the Intensive Care Unit (ICU)
• Determined by their treating clinicians to require both a central venous line and arterial line

Exclusion Criteria:

• None